Tag Archives: HIV-1
HIV-1 alters mitochondria in neurons and contributes to HIV-associated neurocognitive disorders
Human immunodeficiency virus type-1 (HIV) enters the brain during the initial stages of infection and can cause neurologic dysfunction. Despite the success of HIV treatment through combination antiretroviral therapy (ART), impaired neurocognitive function remains an important problem
On-demand, self-administered fast-dissolving insert for prevention of HIV, HSV, and HPV infections
Microbicides are a potential discreet prevention method for empowering millions of women worldwide to protect themselves against incurable sexually transmitted infections (STIs) including HIV, herpes simplex virus (HSV), and human papillomavirus (HPV). For nearly three decades, much
Metformin and AMPK link cancer stem cell elimination with the potential eradication of HIV
Cancer stem cells (CSCs) are cancer cells that exhibit several stem cell-like qualities that are characteristic of embryonic or adult stem cells, including self-renewal, differentiation, and the ability to initiate tumorigenesis. CSCs, similar to adult stem cells
Oocyte activation and latent HIV-1 reactivation: AMPK links the creation of all human life and the potential eradication of HIV-1
In an active area of research known as HIV-1 cure research, the purposeful reactivation of latent/dormant HIV-1 in memory T cells, which induces death of the infected cell or alerts the immune system to the presence of
Locking out HIV from human cells: a new powerful approach
Picture your home, the safest place in the world. And now imagine a criminal that wants to enter and become you home landlord. And imagine that the criminal has the key. What would you do to protect
Immunogenicity of Virus Like Particles (VLP) with modified envelope (Env) protein
HIV uses a special strategy to evade the immune system during the course of infection in a human, based on features of envelope protein. The HIV Env glycoprotein that forms spikes on the surface of virus particles
Does the ethnomedicinal uses of the sour plum tree correlate with its ethnopharmacological properties?
Ximenia caffra Sond. (Fig. 1), commonly referred to as “sour plum” is a common and popular medicinal and fruit tree in the dryland zone in central, eastern and southern Africa. The generic name ‘Ximenia’ commemorates a Spanish
The origin of the HIV-1 epidemic
The epidemic of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, is one of the world’s major public health problems, with around 37 million people currently infected with this virus. The HIV-1 epidemic originated
What type of immune responses are needed to control HIV infection?
Human immunodeficiency virus-1 (HIV-1) infection can be controlled by antiretroviral therapy (ART) for long periods of time, preventing the development of HIV-induced immunodeficiency and AIDS. However, HIV-1 infection cannot be eradicated from immune cells by ART and
AMPK: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome
Although any connection between HIV-1, the virus that causes AIDS, and Hutchinson-Gilford progeria syndrome, a rare genetic disorder that exhibits symptoms of accelerated aging in children, would appear unlikely, splicing of the latent ( i. e. dormant)
HIV-1 pathology: when metabolism meets immunology
“We are what we eat” To this day, the human immunodeficiency virus type 1 (HIV-1) infection is still a public health problem with more than 33 million affected people worldwide with a growing number of cases. Immunology
Reactivation of neutralized HIV-1 by dendritic cells
HIV-1 can be bound by neutralizing antibodies that target the envelope glycoprotein (Env) and thereby block viral entry into HIV-1 susceptible cells. HIV-1 specific antibodies are formed within the first two weeks in patients, but usually these
