Tag Archives: lipid
Lipids keeps shrinking with aging and neurodegeneration
I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. I was immediately fascinated by the elegant code making of the nucleic acids,
Targeting cholesterol metabolism to suppress prostate cancer metastasis
Metastatic prostate cancer is the second leading cause of cancer death in men worldwide. Prostate cancer itself is one of the most common cancers in men. At the early stages, localized prostate cancer usually grows slowly and
Lipid membrane nanosensors for environmental monitoring
Research on environmental and food biosensing remains blooming for two decades now, attracting scientists from diverse fields. From an analytical viewpoint, biosensors offer a number of benefits when compared to the conventional techniques (e.g., chromatography or immunoassays),
Biophysical modulation of lipid model membranes by cobalt and nickel
Cobalt (Co) and Nickel (Ni) are important industrial metals used in the manufacture of a variety of everyday products. Additionally, Co is an essential trace element for humans, involved in the structure and function of vitamin B12.
Lipid modified natural RNA
tRNA is an integral part of the protein translation process. It translates the genetic code from mRNA to make the corresponding protein. The process of protein translation requires a well-defined structure of specific tRNA and its ability
Topical application of hyaluronidase accelerates cutaneous wound healing
Chronic wound care poses a significant biomedical burden. The management and treatment of chronic wounds affect millions of people annually; these numbers are rapidly growing worldwide owing to the increase in the aging population and a sharp
Biophysical characterization of monofilm model systems composed of selected tear film phospholipids
While our eyes are open they are constantly exposed to bacterial infections, injury, and dehydration. To provide the necessary protection against these hazards the outer surface of our eyes is covered by a thin layer known as
Acyl-CoA-binding proteins help plants “degrease” adversities
Serving as the building blocks for triacylglycerides and membrane phospholipids, fatty acids are essential in all forms of life. Given their chemical inertness, fatty acids need activation into a more water-soluble form (as acyl-CoA esters), prior to
A simple assay to measure phosphatidylethanolamine methyltransferase activity
Enzymes are proteins that help chemical reactions to occur within cells and thus, they are essential to their life and function. They produce most of the molecules found in cells, and are classified by their function and
Lipids are major players in Alzheimer’s disease
Alzheimer’s disease is the most common neurodegenerative disorder affecting over 36 million people worldwide. Alzheimer’s patients suffer from dementia and memory loss and go through a progressive, irreversible and eventually fatal loss of cognitive functions. When Alois
New function for the well-known lipids
Angiogenesis is the new blood vessels formation in adult tissues which share some similarities to growth of blood vessels during development called vasculogenesis. It is estimated that growth of any tissue to the sizes above 2-3 mm3
Metformin is a potential remedy for the treatment of Gaucher disease
Glycosphingolipids (GSLs) are amphipathic compounds consisting of oligosaccharides and hydrophobic chain of ceramide. They are ubiquitously distributed in the outer leaflet of the plasma membrane and believed to be involved in a large number of cellular processes,
Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers and blood pressure
Disease of the heart and blood vessels (referred to as cardiovascular disease (CVD)) is the primary cause of death worldwide. A key public health recommendation for reducing the risk of developing CVD is to lower our intake of
Computational refinement and validation protocol for proteins
HIV protects itself using a membrane layer of lipids which covers all proteins which could potentially be targeted by drugs. The only exposed proteins, gp120 and gp41 form spikes that protrude out of the lipid membrane. These
