Tag Archives: multiple sclerosis

Inhibitors of intracellular enzymes for treatment of multiple sclerosis

The protein kinase inhibitor imatinib

Lymphocytes are white blood cells that are central in the immune response to foreign microorganisms. Like all cells, lymphocytes have a membrane, a lipid bilayer, that envelops the content of the cell. Proteins attached to the cell

Multiple sclerosis diagnosis from cerebrospinal fluids via infrared spectroscopy with chemometrics

Multiple sclerosis (MS) is a chronic, demyelinating and degenerative disease of central nervous system (CNS), characterized by an autoimmune inflammation. Approximately 2.5 million people in the world are affected from multiple sclerosis which is one of the

The aged immune system in multiple sclerosis: focus on B cells

Multiple sclerosis (MS) is an autoimmune disorder that affects the brain and spinal cord. A chronic inflammatory reaction causes breakdown of myelin surrounding the axons, leading to a disturbed transmission of nerve impulses. Symptoms of MS include

Epigenetics and multiple sclerosis

Genetic studies have long been trying to describe the etiopathology of human diseases. Even though the cutting-edge approaches like whole human genome sequencing and genome wide association studies have largely improved our apprehension, there are numerous questions

MRI with GBCAs – Practical help to ensure patient safety

Malayeri et al writes: “At present, there is no evidence suggesting that gadolinium deposition in the brain alters neurologic function”. Where is the evidence for this statement? Free gadolinium is highly toxic. Even though no clinical implications

Stress, sex, and sunlight – a different perspective on vitamin D

Low levels of vitamin D in the blood have been associated with a high risk of developing several diseases, including autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, and cancer. Our study group has been working on the role

RIC-3’s effect on nicotinic acetylcholine receptors (nAChRs) and the implications in health and disease

Signal transmission – cells sending and receiving signals from other cells – is the basis of physiology. Everything our body does essentially, is a result of this cell-to-cell communication and innumerable diseases are the results of this

The direct effects of fingolimod in the central nervous system

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS). In people with MS, an immune system error causes lymphocytes (white blood cells) to leave glands known as lymph nodes (where they are stored),

Neurons share the same destiny irrespective of their location: A closer look at PP-MS pathogenesis

Multiple sclerosis (MS) is a disease of the central nervous system, caused by the reaction of immune cells against myelin, a membrane that surrounds the axons of nerve cells. MS is characterized by the presence of inflammatory

Vitamin D and T cells in multiple sclerosis: how to measure an effect?

Multiple sclerosis (MS) is an inflammatory disease of the brain, leading to disability in patients suffering from this disease. A type of white blood cells, T cells, are important pathogenic cells which drive this inflammation in early

Demyelination and remyelination signalling in multiple sclerosis as an aid to targeted therapy

Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) characterised by demyelination. Demyelination, i.e. damage and erosion of the myelin sheath which protects the nerve fibres, occurs in the white matter of

Agreement between physician’s recommendation and fitness-to-drive decision in multiple sclerosis

Multiple sclerosis (MS) is a progressive disease of the central nervous system with potential debilitating effects on visual, motor and cognitive functions. These functions are essential for daily life activities, such as driving a car. Previous studies