Yearly Archives: 2016
A new water-filled channel that transports metabolites of peroxisomes
Peroxisomes are the detoxifier of almost all nucleated cells. Their name was given in respect to their capability of eliminating reactive oxygen species like hydrogen peroxide. As round-shaped membrane enclosed vesicles, they can have variable sizes from
New therapy for itch in the future
Chronic itch is a major and distressing symptom in dermatological diseases including atopic eczema and significantly impairs the patient’s quality of life. In current, millions of people worldwide suffer from chronic itch. However, it is poorly treated.
Placental transfer of the HIV drug dolutegravir in a human ex vivo perfusion model
The fetus of an HIV-positive woman has a 25% chance of becoming infected during pregnancy. HIV medicines have shown to be highly effective in preventing fetal infection with HIV. A part of the efficacy but also the
Erasing atherosclerosis with nanoparticles and near-infrared laser
The advent of nanomedicine and near-infrared (NIR) optics allows the development and design of tools that enhance diagnosis and treatment of atherosclerosis. Clinical application of these technologies is anticipated in the near future. Our trial called NANOM-FIM
A cancers addiction to glutamine affects the whole body and could lead to complex skin rashes
Signs or symptoms far from the vicinity of a developing cancer in the body can give clues of its presence (paraneoplastic syndromes). The skin can offer visible markers of abnormal metabolic activity caused by tumourigenesis, in the
Cutting behavior of three different NiTi endodontic instruments
The objective of the endodontic treatment is cleaning and shaping the root canal system allowing ideal irrigation and obturation. This preparation and disinfection are accomplished by the cutting action of rotary endodontic instruments with the help of
Providing isotopes that can pinpoint disease in the body
President Eisenhower’s “atoms for Peace” initiative started the movement to explore peaceful uses of radioactive atoms, and today one use of radioactivity is to diagnose and treat diseases. Radioactive atoms are unstable atoms that decay by characteristic
Work status of Q fever patients and patients with Legionnaires’ disease
Q fever is an infectious disease that causes flu-like symptoms such as fever and headache, often accompanied by pneumonia. In addition, Q fever can continue to cause symptoms, long after patients became infected. Fatigue is one of
Natural selection favours large size
In many animal populations, bigger individuals often seem to mate more successfully and have a better chance of survival than smaller individuals. On a far larger scale, fossil evidence from some groups of animals suggest that species
Exorcising autoimmunity
Moderately intense physical exercise, performed at regular intervals, is now firmly recognized as a safe and effective intervention by which to enhance quality of life. Despite this awareness, for many of us, as our age increases, so
A new target in the fight against breast cancer
Cancer cells differ from normal cells in many ways, including their abnormal growth and their ability to change shape and migrate to other tissues. These differences are partly caused by changes in the production of proteins and
Blogging as a research methodology
The Arthriting study, the larger study this paper is from, was done to improve our understanding of the daily experiences of young people (aged 11-19) with juvenile idiopathic arthritis (JIA), the commonest type of arthritis in young
HCV controls the export machinery of infected cells to increase its own spread
When a virus infects a cell it changes a lot of the cells functions and behavior to its own benefit. The virus reproduces inside the cell and forces it to release many new virus particles which can
New insights in how nitrite can be involved in cardioprotection
Nitrite, an inorganic ion which abundantly occurs in green leaves and other vegetables, is known to help to prevent and counteract cardiovascular diseases, but the mechanisms involved are still partially unclear. In the attempt to cast light
Inner ear damage affects brain chemistry
Our ability to hear is brought about by the function of our ears. Besides the visible external ears, we have middle and inner ears. Our left and right inner ears, called cochleas (singular cochlea), translate sound vibrations
The source of adipocytes in arrhythmogenic cardiomyopathy
Arrhythmogenic Cardiomyopathy (ACM) is a genetic disorder characterized by progressive fibro-fatty substitution of the heart, arrhythmias and sudden death. It affects mainly young people and athletes. The clinical manifestations, often devious in early phases, are variable. The
Music therapy eases depression, soothes agitation in nursing home residents with dementia
Did you know that around the world there are more than 35 million people living with dementia? People who are diagnosed with dementia, a progressively worsening disorder that affects memory, often experience a sad mood, agitation, and
Ancient DNA supports the western Carpathian Basin as a corridor of the Neolithic expansion
Szécsényi-Nagy et al. reported in a recent paper an exceptional large Neolithic mitochondrial (mtDNA) and Y-chromosomal DNA dataset from the East-Central European Carpathian Basin. The study region was an essential waypoint on the Continental route of the
Major amputation in the management of advanced limb melanoma
Melanoma is an aggressive type of skin cancer that can recur at the original excision site or spread to nearby areas of the body (called “in-transit” metastases), to the lymph nodes that drain that region and/or to
Simple method to assess health risk of vehicle interior pollution
In recent years, a vehicle cabin has been recognized as an important indoor environment for people often go working, shopping, traveling, school and home with vehicles. Unfortunately, people can exposure to airborne VOCs pollution in vehicular cabins.
