What pH at the sites of calcification of an octocoral tells us

What pH at the sites of calcification of an octocoral tells us

Corals are marine organisms which elaborate calcium carbonate skeletons, a process known as biomineralization or calcification. More »

Zinc promotes myoblast differentiation activating Zip7 transporter and Akt signalling pathway

Zinc promotes myoblast differentiation activating Zip7 transporter and Akt signalling pathway

Skeletal muscle is a heterogeneous, dynamic and plastic tissue, which comprises 40% of adult human body mass. More »

Any cell organelle can be the starting point for toxicant and pathogen-induced cell death

Any cell organelle can be the starting point for toxicant and pathogen-induced cell death

Toxicants and pathogens often induce death of their target and host cells. In order to investigate the different ways they can achieve this More »

Metal-organic framework with dangling sulfonate groups for enhanced proton conductivity

Metal-organic framework with dangling sulfonate groups for enhanced proton conductivity

Metal-organic frameworks (MOFs) provide a versatile platform for tuning the chemical functionality of pore surfaces and thus have attracted an increasing amount of attention for applications in gas storage More »

 

Function matters: visual stimulation protects the retina against ischemia

AoS. Function matters: visual stimulation protects the retina against ischemia.

Retinal ischemia is a condition involved in several prevalent retinal degenerative diseases such as glaucoma and diabetic retinopathy, which cause visual impairment and blindness. Current research focuses on the development of neuroprotective strategies against ischemic retinopathies, but

Why constrain human taxonomic diversity?

Although the discovery of ancient humans remains was first reported in 1833, the Neanderthal bones from Feldhofer Grotto were the first to receive a species name: Homo neanderthalensis (King 1865). In 1894, Dubois boldly referred “ape-man” specimens

Allosteric degraders of EGFR leading to cancer cell detachment-promoted death

AoS. Allosteric Degraders of EGFR Leading to Cancer.

Epidermal growth factor receptor (EGFR) allosteric tyrosine kinase inhibitors (TKIs) have emerged as a therapeutic option for overcoming drug resistance in cancer. We have developed furfuryl derivatives of 4-allyl-5-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4H-1,2,4-triazole-3-thiol and have shown that these compounds bind to

The minimally invasive and percutaneous ways: A tale of two approaches for heart valve implantation

AoS.The minimally invasive and percutaneous ways.

Over the decades, advances in medicine have led to large increases in life-expectancy, a fact most are grateful for. However, accompanying this boost in longevity we also find a rise in what are known as “aging-related diseases”,

How to reduce salt in bread by fooling taste

AoS. How to reduce salt in bread by fooling taste

Reducing sodium dietary intake is a global priority in public health. The World Health Organization (WHO) recommends sodium intake for adults to be 2 g/day maximum, equivalent to 5 g/day of cooking salt (sodium chloride, NaCl), whereas

Plasma cell myeloma: an integrated diagnosis of multiple dimensions

AoS. Plasma cell myeloma.

Plasma cell myeloma, a neoplastic proliferation of plasma cells, is one of the most common malignancies in the world. The clinical symptom and treatment response of individual patient are variable, which may relate to the underlying heterogeneous

Lipids keeps shrinking with aging and neurodegeneration

AoS. Lipids keeps shrinking with aging and neurodegeneration.

I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. I was immediately fascinated by the elegant code making of the nucleic acids,

Prevention of congenital heart anomalies: the secret kept by embryonic stem cells

AoS. Prevention of congenital heart anomalies

CITED2 is a transcriptional modulator involved in the regulation of the expression of many other genes in vertebrates. At very early stages of embryo development, CITED2 is particularly important for heart formation, a process also termed cardiogenesis.

DFT for designing efficient supercapacitor electrode materials

AoS. DFT for designing efficient supercapacitor electrode materials.

Josef MacDouall once said “Chemistry is a game that electrons play”. If one were able to know the roles, they could control the game and uncover the mysteries of materials, which are the backbone of our modern

When will my mouse die?

AoS.When will my mouse die?

The maintenance of health is ensured by the function of the three homeostatic systems of the body: the nervous, endocrine and immune systems, and by the net that allows crosstalk between them: the neuroimmunoendocrine communication. With aging,

The olive fruit fly is never alone! Can its bacterial symbionts be useful in managing this olive pest?

AoS. The olive fruit fly is never alone

The notion of individual has changed trough time, and truly, we are never alone as most organisms are entangled in symbioses. As first used in 1879 by Anton de Bary, symbiosis refers to close, long-term associations between

Stimulating nursing students’ interest in community care through curriculum-redesign

AoS. Stimulating nursing students.

Despite increased healthcare extramuralisation, related to increased elderly patients living at home, most nursing students still see the hospital as career favourite. This is problematic, because of the widespread labour-market shortages in community care in many Western

Rapid monitoring of the impact of polymicrobial infections using electrochemical sensors

AoS. Rapid Monitoring of the Impact of Polymicrobial Infections Using Electrochemical Sensors

The development of bacterial infections is a major challenge as pathogenic bacteria spread through healthcare facilities where patients may come in contact with complex bacterial communities heavily colonizing on hospital surfaces. These bacteria cause internal and external

Autophagy suppression decreases craniofacial bone mass

AoS. Autophagy suppression decreases craniofacial bone mass

Macroautophagy (hereafter autophagy) is the main intracellular degradation mechanism to maintain cellular homeostasis by degrading misfolded proteins, recycling dysfunctional organelles, and generating energy fuels under physiological and pathological conditions. Autophagy consists of two major steps: autophagosome formation,

Novel genetics approach identifies GNAS gene as an important prerequisite for β-cell secretory capacity

AoS. Novel genetics approach identifies GNAS gene.

Type 2 diabetes mellitus (T2D) is a major health burden in developing and industrialized countries (www.idf.org). Common genetic variations, susceptibility genes, epigenetic regulation, and miRNAs have been suggested to be profoundly involved in the pathogenicity of T2D. 

Biodrying. A novel technology to treat organic wastes

AoS. Biodrying.

Different reuse pathways for sewage sludge (SS) produced in wastewater treatment plants (WWTPs) and other organic waste exist, such as its direct application as agronomic soil or with a previous composting process to enhance the agronomic qualities

Soil and water bioengineering – Sustainable erosion solutions for the Mediterranean

AoS. Soil and water bioengineering

Accelerated soil erosion and loss is a serious environmental problem, particularly for the Mediterranean region, due to its long history of human pressures, seasonally contrasting climate and rugged topography. Anthropogenic activities such as agriculture, deforestation, urbanization and

Satiated macrophages produce interferon-beta to orchestrate the resolution of bacterial infection

Acute inflammation is a localized, self-limited host defense mechanism against invading microorganism and tissue injury. Rapid recruitment of white blood cells called neutrophils (polymorphonuclear neutrophil granulocytes) from the blood to the site of infection or injury is

Reuse of third generation industrial waste

As global consumption of finite raw materials continues to rise, so too does the amount of waste produced. In Europe for example, each citizen consumes an average of 15 tonnes of raw materials and produces on average

Duloxetine: a promising perioperative analgesic

Atlas of Science. Duloxetine: A Promising Perioperative Analgesic.

Duloxetine is a dual serotonin-norepinephrine receptor inhibitor that is commonly used as an antidepressant. This drug has traditionally been used for chronic pain conditions, such as fibromyalgia and back pain, showing positive recovery outcomes. Given these analgesic