Tag Archives: antibody
Arming macrophages to stop cancer progression
Macrophages are a type of immune cells that fight infection and support tissue remodeling. They are best known as phagocytes which engulf bacteria and damaged cells stimulating other immune cells. In addition, macrophages assist wound healing processes
A molecular passport authorizes intracellular travel for a potential cancer therapy antibody
Whether from external environmental factors or spontaneous intracellular processes, the DNA in our cells is under constant bombardment by DNA damage. Because unrepaired DNA damage can cause cell death, our cells have evolved vital mechanisms to repair
Exploring the potential of a pneumococcal vaccine to target oxidized LDL in metabolic disease patients
Lipid metabolism involves a wide range of processes in which lipids are processed and used as energy sources, signaling molecules and structural elements of cells. Given its importance, dysfunctions in lipid metabolism, both small and large, can
Photonic biosensors for mycotoxin detection in milk
Contamination of food and agricultural products by various types of toxigenic molds (fungi) is a serious and global problem. Fungal toxins, in particular, mycotoxins produced by several species of fungi are naturally present in food species such
Ultrasensitive enzyme immunoassay by immune complex transfer method
Many technologies have been developed to improve the sensitivity of immunoassays, such as high affinity antibodies, specific conjugations using the hinge region of Fab’ fragments, highly active enzymes, and digital counting systems. We described a methodology called
Novel biosensors for the rapid detection of toxicants in foods
The specific objective of this monograph is mainly to exploit progress in nanosciences to deploy nanotechnology in affordable, mass-produced sensors, and to integrate these into components and systems (including portable ones) for mass market applications in environmental
A vaccine candidate for Zika with potential for reduced risk of antibody-dependent enhancement (ADE)
Zika virus (ZIKV) is a mosquito-borne flavivirus that has rapidly extended its geographic range. Its association with abnormal fetal brain development, sexual transmission, and lack of a preventive vaccine have constituted a global health concern. Designing a
Profiling biologics in circulating human whole blood
Functional and safety assessments of biologics prior to first-in-human (FIH) is key to understand the mode-of-action and safety profile. We have made use of an ex-vivo whole blood assay for its potential in assessment of antibody-based drug
Designer antibody therapeutics
We inhabit a hostile environment and are susceptible to infection by current and future pathogenic organisms (foreign bodies; antigens) resulting from mutation and selection forces. Personal integrity is assured by the humoral and cellular immune system (IS)
Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases
The main role of the immune system is to protect the body from a wide range of foreign invaders. In some cases, the immune system recognizes a part of the body as “foreign” and starts to attack
Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade
Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,
Who is the father of innate immunity?
The thermometer can show that something is wrong with a patient (pyrexia). But it cannot be more specific. Likewise, there is evidence, dating back to the ancient Greeks, that the slight changes in blood serum that occur
Immunogenicity of Virus Like Particles (VLP) with modified envelope (Env) protein
HIV uses a special strategy to evade the immune system during the course of infection in a human, based on features of envelope protein. The HIV Env glycoprotein that forms spikes on the surface of virus particles
Specific synthetic nucleic acids instead antibodies
For a long time immunological methods have been applied in biological research as well as for detection and evaluation of various substances in clinical analysis of body fluids. Serum proteins, antibodies, form integral parts in all variants
Bleeding and thrombosis in a patient with primary antiphospholipid syndrome using norethisterone
Antiphospholipid syndrome is an autoimmune hypercoagulable state caused by specific antibodies, and it is known to be associated with the occurrence of blood clots, or thrombosis, in the veins and/or arteries. However bleeding is rarely associated with the syndrome. Only a few cases
Disguising insulin as an antibody: a Trojan horse for type 1 diabetes prevention
Type 1 Diabetes (T1D) is an auto-immune disease. These diseases appear when our own immune system, which normally protects us from foreign pathogens (viruses, bacteria,…), attacks our own cells. In the case of T1D, T lymphocytes, which
Improved antibody selection with assisting plasmid
When the human body is invaded by foreign molecules, the immune system will be activated to fight against these intruders. This is done with the help of antibodies which act as the defence force of our body.
Antibodies at your pipette tips
Antibodies are essential in our immune system to fight against all sorts of diseases that we could encounter every day. The technological developments over the decade has allowed scientist to isolate target or disease-specific antibodies in the
The thymus: a small organ with a mighty big function
The thymus lies in the chest behind the breastbone and above the heart. Relatively large in infancy, it increases in size until puberty and thereafter shrinks to only a few grams in old age. It consists of
Learning from evolution to target cancer with combinatorial strategies
Chemotherapy is the most prominently used therapy for many cancers yet it effects multiple and, in many cases, unknown targets. Of the most modern advancements in cancer treatment is the targeting of single key gene products, for
