Tag Archives: cancer
Gold “bowtie” coming into reality on two-dimensional MoS2 surface
“Bowtie’’, which is a type of necktie, is very popular in our daily life. In some formal meetings or parties, bowtie is the normal choice to make you look good. Actually, this kind of bowtie structures of
Lipofuscin, lipofuscin-like pigments and autofluorescence
This paper provides a syntethic overview on lipofuscin and lipofuscin-like substances, with particlar reference to their biological significance as well as to their cellular origin and pathophysiological role. Special emphasis is also placed on the mutual relationships between
Compounds from Australian Eucalypts: the next wonder-drug for cancer?
If there is one tree that every Australian can relate to, then it would be the none other than the Eucalypt. No wonder they are considered as the only trees that have the power to unite the
Chromatin remodeling regulates multiple liver functions
Liver is a one of the largest tissues that has the ability to regenerate itself upon stimulation. The liver also performs a variety of complex functions which support body homeostasis including detoxification and providing essential molecules to
The resilient pituitary gland: What happens when the pituitary gland has to be cut during surgery?
The pituitary gland is considered to be the “master endocrine gland”. It is a pea-sized structure located at the base of the brain, important in controlling growth and development and the functioning of the other endocrine glands.
Spectroscopic platform to cut time and resources needed to quantify cancer cell biomarker concentrations
Survivability of a living cell, tissue and ultimately a being is influenced by the state of proteolytic degradation of extracellular matrix (ECM) components; if the dynamics of the degradation is perturbed, regulation of many biological processes such
Leukemia cells rely on vesicles from neighboring stromal cells to resist common cancer treatments
Leukemia is a cancer of white blood cells that occurs in both children and adults. Strides have been made in curing most types of leukemia. However, acute myeloid leukemia (AML) continues to resist the same treatment strategies.
Fully human anti-CAIX antibodies for RCC immunotherapy
Globally, there are roughly 270,000 new cases and 116,000 deaths attributed to kidney cancer occur each year. More than 90% of kidney neoplasms are classified as renal cell carcinoma (RCC), which accounts for 3% of all adult
Inhibitors of gastric acid secretion and gastric cancer
The highly acidic gastric juice is an efficient killer of swallowed microorganisms. This is an important function which is reflected in the tight regulation of gastric acidity involving both nerves and hormones (blood born messengers). The most
A new role for vitamin D3
Mutations in the genome of body cells (somatic cells) can lead to excess activation of signaling pathways and thus to unlimited cellular proliferation and cancer formation. One such cancer-inducing pathway is the Hedgehog (Hh) signaling cascade, which
Nucleus-targeted anticancer drug delivery
Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. However, efficient nuclear drug delivery upon systemic administration remains a
Identification of a novel factor implicated in the resistance of cancer to the therapy
Therapeutic treatment of cancer involves radiotherapy and/or chemotherapy so to generate a large amount of lesions in the DNA. Because cancer cells have reduced capacity to repair DNA lesions and are unable to slow down proliferation, this
Could cancer be cured by inducing an autoimmune disease against It?
Might there be some way to make a microbial protein that the immune system normally overlooks (a “non-antigen”) into a target for an active immune response (an “antigen”)? Could one co-opt the immune system to produce an
Surgery for pancreatic head cancer
Pancreaticoduodenectomy (PD) offers the only chance of long-term survival for patients with pancreatic head cancer. The procedure involves removing the pancreatic head together with the duodenum, gallbladder and most of the common extra hepatic bile duct (Fig.
Nonsteroidal anti-inflammatory drugs attenuate lung carcinogenesis in smoking female mice
Chronic inflammation plays a crucial role in the development of cancer in general and of cigarette smoke (CS) – related lung cancer in particular. Accordingly, anti-inflammatory drugs, among which the extensively used nonsteroidal anti – inflammatory drugs
A novel radionuclide treatment for hormone refractory metastatic prostate cancer
Prostate cancer is the second most common male cancer worldwide and the fourth most common cancer overall. In patients with localized prostate cancer, the five-year survival rate approximates to 100%; however, in patients with distant metastases, it
A new approach in laparoscopic colorectal cancer surgery
Laparoscopic surgery for colorectal cancer has been increasingly performed worldwide because it is less invasive and has superior cosmesis with good surgical outcomes. However, laparoscopic surgery is sometimes excluded as an option for some patients with colorectal
Clinical long-term outcome and reinterventional rate after uterine fibroid embolization
Uterus fibroid presents the most frequent benign gynecological tumor. Almost 40 – 50% of women have fibroids during the life. In about 25 – 30% of a woman, fibroids are symptomatic and can cause, frequent bleeding, pain
Treatment sequencing in metastatic castrate-resistant prostate cancer
The treatment of metastatic castrate resistant prostate cancer (mCRPC) has been rapidly advancing. Years of research effort have culminated, in the approvals of five active agents that prolong patient survival. However, as a practicing clinician, I and
