Tag Archives: cancer
Phospholipase A2 group IVc blocks mammary tumor apoptosis
The Hirosaki hairless rat (HHR) is a mutant rat strain with autosomal recessive inheritance spontaneously derived from the Sprague-Dawley rat (SDR). The hairless phenotype of HHRs is due to the deletion of basic hair keratin genes, and
Sugars in circulating blood reflect breast cancer biology
In our studies, consisting of measurements and analyses, we have shown that the sugar composition in the serum of breast cancer patients reflects the biology of their breast tumours. Patients with different kinds of breast tumours have
Effect of resveratrol on chemotherapy of a fatal childhood cancer
The natural polyphenolic compound resveratrol, found in red wine, dark chocolate, and peanuts, may confer health benefits in humans. It is a powerful antioxidant that has been suggested to alleviate age-related pathologies, such as type II diabetes,
A method for studying mouse mammary tumorigenesis
Metastasis is the last step of primary breast cancer progression in which cells from the primary tumor leave and go to other organs. Breast cancer cells often metastasize to the lung, among other organs. Each step in
How to improve outcome in patients with primary appendiceal mucinous cancer
Appendiceal mucinous cancers are extremely rare cancers. The management of mucinous appendiceal tumors is mainly based on single-institution experiences. A challenge in the treatment of this disease is that a large number of patients present with disease
Chloroquine inhibits the malignant phenotype of glioblastoma
Glioblastoma (GBM), the most common and aggressive primary brain tumor, is characterized by excessive growth and infiltration of the normal brain which prevents the complete surgical resection. These tumors also are refractory to standard treatment strategies, which
AMPK: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome
Although any connection between HIV-1, the virus that causes AIDS, and Hutchinson-Gilford progeria syndrome, a rare genetic disorder that exhibits symptoms of accelerated aging in children, would appear unlikely, splicing of the latent ( i. e. dormant)
Palpable melanoma groin lymph node metastases
Melanoma is the most lethal type of skin cancer. In 2012 232,130 persons were diagnosed worldwide, and 55,488 estimated deaths occurred due to melanoma. Patients who present with a palpable lymph node metastasis in the groin area
How to optimize the effectiveness of anticancer therapy
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HCC is a public health problem worldwide because of its high incidence and its poor prognosis with high cancer-related mortality. In the majority of cases, patients
Cancer connection: study of inflammation offers tantalizing clues
The body displays a remarkable capacity for healing wounds— a process we often take for granted. Within a day, a finger we’ve carelessly nicked returns to normal. Behind the scenes, a crucial mediator of the body’s inflammatory
Onco-Nephrology: the frontier of cancer and kidney disease
Kidney problems can result from cancer or its treatment. Patients with kidney disease can develop cancer. These clinical problems are challenging and significantly affect morbidity and mortality. Yet until recently they have not had focused attention. Cancer
The prognostic value of tumor markers and cytokines in patients with squamous cell cervical cancer
Optimal management of cervical cancer consists of appropriate treatment methods after the precise staging, following detection as early as possible, and the best salvage therapy. Early detection of recurrence, especially at the early stages in cervical cancer
What does a guardian protect genomic DNA from?
Living organisms can achieve their propagation through copying (replicating) the genetic information, coded in DNA sequence, and dividing them to each daughter cell. DNA sequence is a basic element and its conservation is essential for individual life
The art to irradiate the Internal Mammary Nodes (IMN) in breast cancer patients
Radiation therapy (RT) has demonstrated strong clinical benefit in patients with breast conservative surgery or with radical mastectomy and who are at high risk for relapse. Unfortunately, this benefit was counterbalanced by an increased risk for death
Characterizing the whac-a-mole concept of a bispecific antibody targeting cancer cells
One of the great promises of antibodies is to be magic bullets that specifically target diseased cells without affecting normal cells. Oncology researchers identify targets on tumor cells that are unique, overexpressed, or oncogenic drivers that can
Nanoformulations for cancer therapy
Cancer is a major disease responsible for death in human beings. A lot of research has been performed to develop improved diagnostic tools as well as drugs to treat cancer. Effectiveness of therapeutics in cancerous malignancy is
A new mouse model to study the biology of depression in cancer
Patients with advanced cancers often experience depression, which can significantly reduce their quality of life and increase mortality. Currently, the lack of a valid and useful animal model is the greatest obstacle for studying the basic biology
Over-expression of TRX2 reduces p53-mediated cell death in yeast
The p53 gene is a human tumor suppressor which is involved in cell cycle regulation. It has an efficient ability to inhibit cell proliferation, by both blocking cell cycle progression and promoting apoptotic cell death in order
How cancer cells resist the action of microtubule-targeting chemotherapeutic drugs? A study of β-tubulin mutations
Microtubules (MTs) are essential structural components of cells. They are made up of polymers of protein subunits of α,β-tubulin and are highly dynamic, undergoing rapid phases of assembly and disassembly. The dynamic behavior of MTs is essential
Prostate cancer: prognostic impact of adenosine-generating CD73
Traditionally, most cancers were treated with surgery, radiotherapy or chemotherapy (or a combination of these options). Using the immune system to fight cancer has long been the objective of many researchers, but convincing success in the clinic
