Tag Archives: cell

Microfluidic live-cell microarrays

In recent years, the development of new drugs and therapies has decelerated despite the application of combinatorial biochemistry and new therapeutic strategies, such as nanoparticle-based drug delivery systems. Although the numbers of newly developed compounds have steadily

Metformin is a potential remedy for the treatment of Gaucher disease

Glycosphingolipids (GSLs) are amphipathic compounds consisting of oligosaccharides and hydrophobic chain of ceramide. They are ubiquitously distributed in the outer leaflet of the plasma membrane and believed to be involved in a large number of cellular processes,

Plant flavonoids prevent cancer progression through suppression of new blood vessel formation

Flavonoids are a sub-family of polyphenolic compounds. They are abundantly found in plants and known to have inhibitory properties in the initiation, promotion and progression of invasive cancers. Cancer progression is a complex process. It is mainly

Small-molecule RETRA is effective against a fatal childhood cancer

The bone tumor Ewing’s sarcoma is one of the most aggressive cancers in childhood and adolescence. Before the era of chemotherapy, more than 90% of Ewing’s sarcoma patients succumbed to their disease. With the introduction of intensive

Silence the uncontrolled cancer cells’ growth by controlling cellular senescence

When toxic damage caused by environmental or internal stressors accumulates cells can either stop proliferation permanently ( cellular senescence ) or die. Cell death is a common goal of existing cancer therapies, yet cellular senescence is increasingly

Whole-cell computational models can predict how genes influence behavior

Since the early 1900’s, scientists have known that cells are composed of multiple components, including small molecules, DNA, RNA, and protein. Over the past fifty years, scientists have systematically measured these individual components and their interactions. Despite

A novel approach to identify primitive CD34+ stem cells

Stem cells are important for living organisms for many reasons, as they are capable of renewing themselves as well as to expand to repair and regenerate damaged tissues. Adult stem cells exist throughout the body after embryonic

Epstein–Barr virus in peripheral blood predicts response to rituximab therapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation of the joints that may cause permanent cartilage and bone damage. The cause of RA is unknown. It is, however, believed that a combination of genes

Janus subcompartmentalized microreactors

When we are sick and have to take medicine, the first thing we do, is reading the package leaflet. We want to know the potential side effects of the drug. Sometimes the side effect of one drug

Nuclear membrane diversity

Although it is obvious that every tissue in our bodies is different, the vast majority of scientific research is done on a small number of cancer cell lines studying individual cells grown in dishes — for example

Lipofuscin, lipofuscin-like pigments and autofluorescence

This paper provides a syntethic overview on lipofuscin and lipofuscin-like substances, with particlar reference to their biological significance as well as to their cellular origin and pathophysiological role. Special emphasis is also placed on the mutual relationships between

From cell to society: a nutritional intervention to offset the age-related loss in lean tissue mass

Society is aware of obesity. Defined by the WHO, obesity is an abnormal or excessive fat accumulation that may impair health. A 40y person with normal BMI will progress to obesity at 70y through an annual gain

Advanced green antibacterial materials made by mussel-inspired chemistry

Since ancient times, silver and its salts have universally been employed as antibacterial agents for the treatment of infections, burns and chronic wounds in curative and preventive health care, because of their extraordinary inhibitory and bactericidal properties

Mummification of cells: how dry is dry?

Human cells, the fundamental building blocks of tissues and organs, are often used to replace damaged body parts as well as for the production of certain medicines. However, the long term storage and transport of these cells

What is really driving our need for food, besides the pleasure of taste?

We all know that this need is related, in some way, with life sustainability, but just how, exactly? The task of converting food into energy –and back again into organic compounds– is carried out by our metabolism,

Measuring what cells feel using the nano-epsilon dot method

When we walk on the sand, a trampoline or a concrete pavement, we can feel the hardness, softness and springiness of the ground and respond by changing the way we move. The way we respond depends on

Pass the salt, please! Understanding how cells deal with high salt

Table salt, a molecule made up of the charged ions sodium and chloride, is an essential nutrient fundamental to life and once worth its weight in gold. Historically a precious commodity, salt also helped civilizations develop because

On their way out: Structural HIV proteins team up before escaping from infected cells

The human immunodeficiency virus ( HIV ) infects and eventually destroys the immune cells of infected patients. This causes the life-threatening medical condition called acquired immunodeficiency syndrome ( AIDS ). A cure for HIV/AIDS does not exist,

Zinc – a promising supplement for the immune system

Zinc is essential for basic functions within cells of the human body. Hence, zinc deficiency is associated with impaired immune functions as dermatitis, dysfunction of the immune system, hypogonadism, and growth retardation. Under normal conditions only low

Characterizing the whac-a-mole concept of a bispecific antibody targeting cancer cells

One of the great promises of antibodies is to be magic bullets that specifically target diseased cells without affecting normal cells. Oncology researchers identify targets on tumor cells that are unique, overexpressed, or oncogenic drivers that can