Tag Archives: dementia
The suitability of scopolamine as an Alzheimer’s model
Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of
Painkillers to treat schizophrenia or dementia?
Schizophrenia affects about 1 % of general population and may significantly reduce life expectancy. Drug nonadherence remains a crucial problem in the pharmacotherapy of this disorder. Animal and clinical studies results suggest that abnormal kynurenic acid (KYNA)
Most common behavioral problems in people with dementia
With people all over the world living longer, more and more of them develop problems with brain functions. Some of these problems are mild, e.g. slight forgetfulness, but some may interfere with their daily activities, such as
Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease
Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million
Dementia with Lewy bodies and Parkinson’s disease-dementia: Current perspectives
Dementia with Lewy bodies (DLB) and Parkinson’s disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology. Both disorders show notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk
Alzheimer’s risk gene weakens brain cell’s garbage disposal system
APOE ε4 is the most common genetic risk factor for development of Alzheimer’s disease. Having two copies of this gene (one from the mother and one from the father) increases a person’s relative risk to as much
Sopping assistance with eating and drinking in severe dementia
More and more people will develop some form of progressive dementia because of increasing life span in most countries. Since there is no effective therapy for Alzheimer’s disease and other progressive dementias, about 50% will die at
Management of apathy in the long-term care setting
Management of apathy is a very important issue in the long-term care because many residents with neurodegenerative disorders suffer from this syndrome. In Alzheimer’s disease, apathy is the most common behavioral syndrome and may occur already in
CSF-1 receptor and its activators – new players in the nervous system and neurological disease
Macrophages, meaning big eater (from the Greek, makros (large) and phagein (to eat)), are cells, present in all tissues of the body, that engulf and degrade large foreign particles, such as microbes and also scavenge abnormal self
Dementia and successful ageing after 100: An international consortium
Up until recently, centenarians and near-centenarians (i.e. 95 years and above) were considered outliers – few and far between – who had somehow beaten the odds and survived to the very limit of the human lifespan. According
Mild cognitive impairment in older people around the world
The global population is ageing rapidly, and bringing with it an increase in the number of people experiencing physical and mental health conditions associated with older age. Mild cognitive impairment (MCI) is a common condition among older
Early-onset Alzheimer disease: what are we missing?
Memory is the first brain function that starts to fade away when Alzheimer disease (AD) pathology affects the brain of a patient. Decline of additional cognitive functions, shortly follows. This progressive and irreversible disease, intrudes the life
Understanding why behaviours are challenging for dementia family carers
Dementia is a global health challenge that confronts health and social care systems today. It is characterised by global cognitive impairment. However, it is the disruption to daily living and in particular the non-cognitive, (behavioural and psychological)
Physical activity helps to reduce cognitive symptoms for dementia patients
Dementia is a clinical syndrome characterized by cognitive symptoms, which lead to disruptions in many aspects of daily life. The most common type of dementia is Alzheimer’s disease, which affects 5.3 million people in the United States
Music therapy eases depression, soothes agitation in nursing home residents with dementia
Did you know that around the world there are more than 35 million people living with dementia? People who are diagnosed with dementia, a progressively worsening disorder that affects memory, often experience a sad mood, agitation, and
Promote the health of dementia caregivers
The vast majority of the care for people with Alzheimer’s dementia is and will be carried out by informal caregivers as health care services across the world cut funding. This is a major concern in an aging
A promising new drug treatment for Alzheimer’s disease
Diabetes is a risk factor for developing Alzheimer’s disease (AD). The underlying mechanism seems to be that insulin signaling in the brain of patients with AD is very much impaired. Insulin not only controls blood sugar levels,
