Tag Archives: drug discovery

Cryo-electron microscopy in drug development

AoS. Cryo-electron microscopy in drug development

Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for

Advances in drug discovery and development in geriatric psychiatry

Drug discovery for disorders of the central nervous system is a long and challenging process, with a high attrition rate from the preclinical stages through to marketing a compound. In geriatric psychiatry, the heterogeneous nature of these

A new strategy to drug development for neuromuscular disorder

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disease in which motor neuron (MN) loss in both the spinal cord and motor cortex causes progressive paralysis, muscle atrophy, and death. So far,

Cellular assay: bottleneck of the drug discovery process

Finding a needle in the haystack is not that difficult after all: Just use a strong magnet, and you have a good chance to get it. Picking up, among millions of different compounds, the right ones that

Proline analogues present anti-Trypanosoma cruzi activity through inhibition of proline transporter

Trypanosoma cruzi is the protozoan parasite that causes Chagas disease, an illness that affects approximately 7 million people in Latin America. Nowadays there are only two drugs approved for Chagas treatment, benznidazole and nifurtimox. Both drugs were

A new drug combination rescues a rare Cystic Fibrosis mutation in patient tissue

University of Toronto researchers in the laboratory of Dr. Christine Bear, together with collaborators at SickKids Hospital (Toronto, Canada) and Proteostasis Therapeutics (Cambridge, Massachusetts), used computer simulations, cell-based systems and patient tissue to interrogate the consequences of

How to use machine learning to discover relevant aspects in the Dengue Virus protease and guide the drug discovery process?

Dengue Virus (DENV) is perhaps one of the most relevant viral pathogens in tropical and sub-tropical areas. A World Health Organization (WHO) report indicates that DENV related infections have increased 30-fold in the last 50 years. DENV

3rd International Conference and Expo on Drug Discovery & Designing. Vienna, Austria. October 02-04, 2017

Conference Series has taken an initiation to conduct international conference and Expo on Drug Discovery & Designing workshops worldwide . From last 3 years Conference Series has been conducting Drug Discovery & Designing conferences in major continents

A multistep virtual screening approach to identify proteasome inhibitors

Proteasome plays a fundamental role in the protein turnover by degrading misfolded, abnormal or damaged proteins, previously labeled through addition of a polyubiquitin chain. An aberration of this proteolytic system could result in different types of hematological

Small fish can help finding drugs to fight retina diseases

About 285 million people are visually impaired in the world. The arising of chronic eye diseases and ageing processes make more people at risk of blindness, 65% of visually impaired people being aged 50 or older. Among

The apothecary inside us

New drugs might be found right under our noses or, more precisely, in our guts as we learn more about the ways metabolites from intestinal bacteria modulate human metabolic and immunity pathways.  Our recently published paper in

Combining paper-based electrochemistry and mass spectrometry

Electrochemistry / mass spectrometry ( EC / MS ) has many applications in science and industry such as drug discovery, elucidation of redox mechanisms, identification of drug metabolites, and online chemical derivatization for improving analytical figures of

Making drug discovery more efficient: predicting drug side effects in early screening efforts

Drug research and development is a complex and expensive process that begins with initial screening steps of candidate chemical compounds. Compounds that appear to have the desired potency against a specific cellular target or pathway are further

Small fish can help finding antimalarial drugs with less severe side effects

In 2012, over 200 million cases of malaria have been reported. Vaccines for malaria are under development; however, no generally accepted vaccine that also works for adults is yet available. Therefore, drugs will in the foreseeable future

Finding new drug targets to prevent heart attacks and strokes

Heart attacks and strokes are responsible for more deaths than any other disease in the world. The underlying cause of most heart attacks and strokes is a disease of the blood vessels called atherosclerosis. Atherosclerosis involves accumulation

3D environment enhance cellular capacities

Although we live under the 3D (three-dimensional) environment, drug testing is carried out usually by using isolated cells cultured under the 2D (two-dimensional) environment. Liver is a very important organ which metabolizes glucose, alcohol, lipids (e.g. cholesterol)