Tag Archives: malaria

Complexity of malaria dynamics under climate change

The transmission of malaria is highly variable and depends on a range of climatic and anthropogenic factors. For more than two decades, there has been a growing concern and hot debate over the impact of global warming

A powerful tool for the study of CD4 T cells in malaria

Although aimed at controlling invading pathogens, immune responses can sometimes be harmful to the host. Responses against the blood stage of malaria are an example of this: while B cells are activated and produce useful antibodies that

Risk of malaria reemergence in Bulgaria

Malaria is a disease of high medical and social importance. Notwithstanding the efforts of WHO and national systems of public health, it is still widespread over large areas around the globe and it is a cause for

Lessons from the Global Fund’s fight against AIDS, Tuberculosis and Malaria

At the beginning of this century, developing countries – particularly in Africa – experienced rapidly rising illness and death from AIDS, Tuberculosis, and Malaria. The three diseases caused massive suffering and economic damage. Treatment and interventions to

Malaria and hypertension-a new hypothesis in clinical medicine

Research from University College Cork, Ireland and New York University School of Medicine, USA has shown a credible link to the high rate of hypertension, stroke, and myocardial infarction amongst Africans and Afro-Americans, and a genetic defence

Producing cellular transport proteins without cells: a key to study novel molecular targets of malaria parasites

Malaria tropica, the most severe and fatal form of malaria, is caused by mosquito-transmitted, single-celled Plasmodium falciparum parasites. More than 3 billion people in 100 countries live in malaria-endangered areas. Every year, > 200 million new infections

Biological larviciding against malaria mosquitoes in rural West Africa – A cost analysis

Malaria is still the most common vector borne disease in Africa, although the number of cases and deaths was reduced by 18 and 48% respectively since the 2000s. In 2015 some 188 million people fell sick from

Artemisia annua leaves improved solubility of antimalarial drug, artemisinin

Artemisia annua L., also known as Sweet Annie, is a Chinese medicinal herb that produces the important antimalarial drug, artemisinin. Artemisinin is the most powerful antimalarial ever discovered and its derivatives are the main component of artemisinin

Do roots rule anti-malarial artemisinin production in Artemisia annua leaves?

Artemisinin is an anti-malarial molecule that is produced and stored in the leaves of the plant Artemisia annua in microscopic glandular surface structures called trichomes (Fig. 1). Evidence from various studies suggests that the roots, which produce neither significant

Holding the last line of defence against malaria

Malaria contributed to the deaths of almost half a million people worldwide in 2015. This disease mainly affects people in the developing countries and imposes a serious health and financial burden. Artemisinin (ART)-based combination therapy is the

Warming and increased rainfall are changing malaria hotspots in the highlands of Burundi

Children under five years old are more affected by malaria than any other age group, accounting for 78% of malaria related deaths in 2012. Sub-Saharan Africa has the largest burden of malaria deaths world-wide, with 229,486 of

Small fish can help finding antimalarial drugs with less severe side effects

In 2012, over 200 million cases of malaria have been reported. Vaccines for malaria are under development; however, no generally accepted vaccine that also works for adults is yet available. Therefore, drugs will in the foreseeable future

Forecasting malaria using environmental and clinical predictors

In 1911, Christophers developed an early-warning system for malaria epidemics in Punjab based on rainfall, fever-related deaths and wheat prices. Since that initial system, researchers and practitioners have continued to search for determinants of spatial and temporal