Tag Archives: therapy

Demyelination and remyelination signalling in multiple sclerosis as an aid to targeted therapy

Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) characterised by demyelination. Demyelination, i.e. damage and erosion of the myelin sheath which protects the nerve fibres, occurs in the white matter of

The potential of LINGO-1 as a therapeutic target for essential tremor

Essential tremor (ET) is probably the most common movement disorder. Because the etiology of ET is unknown, treatment of ET is symptomatic and is geared towards reducing the patient’s embarrassment and disability. The first line treatment is

Time for a new understanding of chest pain

Most people who present to hospitals with pain in the chest have nothing wrong with their hearts. A small proportion have another physical problem such as acid reflux from the stomach but most have health anxiety or

A natural compound called rutin may shade light on diabetes therapy

Diabetes and its major risk factor, obesity, have become a world-wide epidemic and cause of suffering for millions of people. There is still no drug of cure for diabetes and the currently available drugs suffer from a

Complementary therapies can increase survival in cancer patients

It is well known that a large percentage of cancer patients use some form of complementary and alternative medicine (CAM), usually with the goal of improving quality of life, providing supportive care as well as  relieving pain

CITED1 is a potential therapeutic target for metastatic melanoma

Cancer kills over 8 million people every year. What makes it so deadly is its ability to spread from the organ where it originates to the rest of the body, a process known as metastasis. Even though

Electroconvulsive therapy without seizures?

Electroconvulsive therapy (ECT), sometimes called “electroshock therapy” is considered the most effective short-term treatment available for major depression. The procedure involves passing electrical current through the brain with electrodes placed on the scalp and is done in

A functional immune system against cancer in breast cancer patients

One of the hallmarks of cancer development is the ability of tumor cells to evade the recognition by the host immune system. However, the presence of immune responses against cancer is frequently observed in cancer patients. The

A combination therapy to induce apoptosis in difficult-to-treat cancer cells

The presence of activated PI3K-AKT is a major obstacle to successful chemotherapies. Since PI3K-AKT is activated in many healthy tissues, chemical inhibitors of PI3K-AKT inevitably have many unwanted side effects. By using a cholesterol-targeting drug called beta-cyclodextrin

Minimizing injuries from acute myocardial infarction

Reperfusion therapy is currently the mainstay treatment of acute myocardial infarction, as it salvages myocardial cells from ischemic cell death. However, abrupt restoration of coronary blood flow induces another type of cell death called “lethal reperfusion injury,”

Potential for therapeutic intervention in lung diseases

The major function of the lung is to enable ambient oxygen uptake (essential for life) and eliminate carbon dioxide (a waste byproduct of metabolism) from the body. Surfactant protein A (SP-A), is a protein found in the

A new role for vitamin D3

Mutations in the genome of body cells (somatic cells) can lead to excess activation of signaling pathways and thus to unlimited cellular proliferation and cancer formation. One such cancer-inducing pathway is the Hedgehog (Hh) signaling cascade, which

Identification of a novel factor implicated in the resistance of cancer to the therapy

Therapeutic treatment of cancer involves radiotherapy and/or chemotherapy so to generate a large amount of lesions in the DNA. Because cancer cells have reduced capacity to repair DNA lesions and are unable to slow down proliferation, this

A small structure hidden in the brain that might play a big role in diseases like depression and autism

The choroid plexus is a hidden and often neglected, but important, structure in the brain. The choroid plexus hangs inside the brain ventricles which are filled with cerebrospinal fluid (CSF) (Fig. 1). Importantly, the choroid plexus is

Effect of resveratrol on chemotherapy of a fatal childhood cancer

The natural polyphenolic compound resveratrol, found in red wine, dark chocolate, and peanuts, may confer health benefits in humans. It is a powerful antioxidant that has been suggested to alleviate age-related pathologies, such as type II diabetes,

Nanocarrier-based antioxidant therapy: promise or delusion?

It has been well established that the damage produced by Reactive Oxygen Species (ROS), which are highly reactive molecules with an unpaired electron, plays an important role in a large number of human diseases. Because of this

How to optimize the effectiveness of anticancer therapy

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HCC is a public health problem worldwide because of its high incidence and its poor prognosis with high cancer-related mortality. In the majority of cases, patients

Nanoformulations for cancer therapy

Cancer is a major disease responsible for death in human beings. A lot of research has been performed to develop improved diagnostic tools as well as drugs to treat cancer. Effectiveness of therapeutics in cancerous malignancy is

New drugs for cancer treatment

Cancer is a major cause of death and more than 1 million people in the United States are diagnosed with cancer each year. Finding more effective methods to treat cancer remains a challenge, and researchers are working

Blood-based biomarkers for multiple sclerosis

Multiple sclerosis (MS) is an immune-mediated, inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). MS is classified in: relapsing–remitting (RRMS), characterized by acute attacks followed by partial or complete recovery periods; primary progressive (PPMS),