Monthly Archives: December 2016
Antimicrobial peptide-loaded hyaluronic acid nanogels as a new strategy for tuberculosis therapeutics
Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, is one of the most deadly infectious diseases, along with HIV/AIDS. According to the most recent data, 9.6 million new cases of TB were diagnosed worldwide
Mechanism of AAA rupture and its potential prevention strategy
Abdominal aortic aneurysm (AAA) is a fatal disease that involves gradual dilation of the abdominal aorta followed by its rupture. However, the mechanism of AAA rupture is not fully understood yet. Although AAA is one of the
Lymphocytes T and Treg as prognostic factors of newly diagnosed DLBCL patients
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and most common form of non-Hodgkin lymphoma. The mechanism of DLBCL pathogenesis is not fully understood. Malignant B-cells responsible for lymphoma formation are believed to arise from different stages
Injectable composite made of nano tubular clays and polysaccharide matrix
The research in the bone medication field is constantly aiming at developing effective strategies and new materials to treat bone defects. Minimally invasive surgery, for instance, represents a valuable option since it ensures several benefits, such as
A new PARADIGM for neurohormonal therapy in heart failure
Heart failure is a leading cause of hospital admissions and mortality worldwide. With an aging global population and enhanced survival after myocardial infarction, heart failure prevalence will almost certainly rise in the future. Although existing therapies have
High fidelity computer simulation to predict damage in advanced ceramic composites for nuclear energy
Composite materials, made from ceramic fibres within a ceramic matrix, can have excellent strength and tolerance to damage at very high temperatures. They have been chosen to protect the fuel in some future designs for advanced nuclear
Dance and age well
Regular ongoing participation in ballroom dance contributes to successful aging. While its physical and cognitive demands promote function, its enjoyment fosters a sense of well-being. In particular the love of dance enhances positive well-being. Dino’s description of
Towards photovoltaics on curtains
Development of various devices for consumption of solar energy offers a range of new possibilities for a customer. When I imagine how we can collect solar energy, the first impression is a massive barrel on the roof
Characterization of the cell surface receptor GPR101: a molecular biology detective work
What did we know about GPR101 until a couple of years ago? Very little. The human gene was discovered in 2001, found to be located on chromosome X, and predicted to encode a seven-transmembrane receptor. In the
Can prolonged exposure to cortisol excess have an irreversible effect on emotion-related brain areas?
Cortisol is a hormone produced in humans by adrenal glands and it is necessary to live. In healthy people, cortisol level naturally increases in response to stressful situations, but when cortisol level in the body is too
‘Uberizing’ home care in Ontario
A strong home and community care system can contribute considerably to a sustainable healthcare system and to improving patient care, reducing healthcare system costs, decreasing lengths of hospital stays and shortening wait lists for long-term care. Unlocking
The effectiveness of the cuticular transpiration barrier of a desert plant
The efficient control of water loss from plant organs to the atmosphere is essential to enable plant survival. The water loss regulation mainly occurs via the stomata, small adjustable apertures controlling the gas exchange. Drought induces stomatal
An RNA degradative enzyme that stimulates breast cancer cells to move and invade
RNA degradative enzymes carry out key steps in regulating gene expression. They are broadly grouped into two groups; exonucleases, that degrade RNA from one end and endonucleases, which cut within the body of an RNA molecule. PMR1
A new trehalose-conjugated peptide protects neurons from Aβ’s oligomers insult
Alzheimer’s disease (AD) is by far the most common cause of dementia affecting more than 35 million people worldwide. AD is characterized by memory loss, dramatic impairment of cognitive skills, and progressive body and mind decline ultimately
Antireductants – essential counterparts of antioxidants
The hype around ‘antioxidants for health’ largely overshadows the existence of antireductants. While antioxidants by definition decrease oxidative stress, antireductants decrease reductive stress (Fig. 1). Despite opposite reactivities, antioxidants and antireductants have in common that they are
A detection and reporting health system of occupational diseases
The Valencian Community in Spain has a system of communication of suspicions of occupational diseases (OD) developed by the General Public Health of Universal Health and Public Health Department, based on the current schedule of occupational diseases
Infections erode transplantation tolerance
Organ transplantation is an effective means of treating patients with organ failure, but rejection of the graft remains a major challenge. The life-long use of immunosuppressants needed to prevent rejection makes transplant recipients more susceptible to infections
Why are all button mushroom cultivars similar?
Button mushrooms (Agaricus bisporus) are very popular edible mushrooms. However, for such an important crop only few genetically different cultivars are available. One of the main reasons for this is the unique way in which the genetic
Prolonged survival with quality of life can come true by using low-dose pazopanib maintenance
Currently, pazopanib is used as a second- or third-line adjuvant chemotherapeutic in patients with soft tissue sarcoma, given at a fixed dose of 800 mg once a day. However, pazopanib has many side effects, and there is
Interaction of ZnO nanoparticle with biological system
Zinc oxide nanoparticles (ZnO NPs) are one of the few nanoparticles synthesised industrially. This nanoparticle possesses a broad spectrum of application in rubber industry, optoelectronics, biomedical sector and pharmaceutics. With extensive applications the exposure risk also increases
