Monthly Archives: April 2017
Epileptic encephalopathies in children: Animal models may change the word “catastrophic” to “hopeful”
Seizures are a sign of brain dysfunction caused by abnormal, hyperexcitable brain circuits. Clinical seizures range from brief staring spells to massive whole – body convulsions. The developing brain is especially prone to seizures and seizure-related brain
Gangliocytomas of the seller region: present and future
Gangliocytomas are well-differentiated tumors formed by irregular groups of large multipolar neurons, often with atypical characteristics. They are benign tumors and a complete tumor resection is considered curative. Their localization in the sellar region is extremely rare
How Americans remember and forget the U.S presidents
Groups of people remember and forget events that occurred in the past, just as individual people remember and forget events occurring in their lifetimes. The study of the memories of a group is called collective memory, and
Adolescent exposure of MDMA potentiates one of the hallmarks of Alzheimer’s disease
3,4 Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative widely consumed by adolescents, which has been described that produces oxidative stress in neurons such as dopaminergic neurons. Moreover, many patients with Alzheimer’s disease develop extrapyramidal symptoms due to alterations
Autism training: the one-eyed wo/man in the land of the blind
The number of people diagnosed with autism is on the rise. According to figures revealed in the Millennium Cohort Study (n= 13,287 families), autism prevalence rates in the United Kingdom (UK) are 3.5% of 11-year-old children. In
The use of bone marrow-derived mononuclear cells ameliorates airway inflammation in horses with recurrent airway obstruction
Horses stabled indoors live in a pro-allergenic environment and are exposed to molds, mites, and bacterial endotoxins from hay and bedding. This exposure exacerbates recurrent airway obstruction (RAO), an asthma-like disease. Affected horses suffer from recurrence of
Making 8-membered rings – It’s a DOS (diversity orientated synthesis) approach
For many years, the primary method of global drug discovery has involved the synthesis of naturally occurring molecules and their derivatives. This drug discovery process would involve several steps, from initial extraction and isolation from a biological
Simulation by Stanford researchers shows how transporter proteins do their work in cells
Cells must continually pass molecules in and out to sustain life. Computer scientists and molecular physiologists have developed a computer algorithm to capture how these crucial proteins work. Inside every plant or animal, proteins called transporters act
Mid ventricular ballooning in takotsubo cardiomyopathy: from a concealed to a manifest form
Myocardial bridging occurs when one of the coronary arteries (left anterior descending coronary artery, cicumflex artery and right coronary artery) tunnels through the myocardium rather than resting on top of it. Typically, the arteries rest on top of the heart muscle and
To get your target compound quickly with the TLC-based GUESS working chart
Choosing a suitable solvent system for a counter-current chromatography separation presents a challenge for many researchers. In this study we introduce a quick method of separating a target compound from the bark of Zanthoxylum myriacanthum var. pubescens
Type I interferons fuel adipose inflammation in obesity
When people get fat the visceral adipose tissue (VAT), fatty deposits inside the body that cling around the internal organs, get inflamed. This chronic low grade inflammation is termed metaflammation. Metaflammation has been found to contribute to
Deciphering plant immunity against parasites
A research group at University Bonn uncovers how plants detect and defeat parasitic worms. Nematodes are a huge threat to agriculture since they parasitize important crops such as wheat, soybean, and banana; but plants can defend themselves.
Prostate-specific antigen 1.5: The new screening protocol
Prostate cancer is the leading cause of cancer-related death in American men. Tragically, once the disease is spread beyond the prostate gland, therapies become very limited and survival is poor. Like other cancers, prostate cancer can recur
Unusual structure of aggregates formed by the fragment of Аβ(16-25) peptide
By the moment, a large number of proteins and peptides, polymerization of which in fibril formations leads to emergence of different diseases (amyloidosis), have been identified. But it is not always that fibril formations are toxic for
Proofread or Perish: Editing your scientific writing for successful publication
Perhaps the consequences of neglecting to proofread and edit scientific writing may not be quite as catastrophic as my heading implies, but viewed from a perspective focussed on successful publication, they can be most unpleasant and are
Is inversion symmetry of chromosomes a law of nature?
Chargaff has made, in 1950, the important observation that the numbers of nucleotides in DNA satisfy #A=#T and #G=#C. This played a crucial role in realizing that DNA has a two strand structure with base-pair bindings (of
A novel deep learning-based method for predicting RNA-protein interactions
RNA-binding proteins (RBPs) take over 5–10% of the eukaryotic proteome and regulate the gene localization and translation. On the other hand, the mutations in RBPs have been discovered to be associated with disease risk, such as FUS
Will exposure of irritant chemicals to the eye lead to adverse systemic outcome?
Eye is a delicate and highly vascularized organ. It captures visible light and converts it into sensory inputs with the aid of the retina and central nervous system subsequently giving rise to vision. Any chemical or drug
Synergistic effects of orally delivered cannabis constituents (THC and CBDA) in reducing nausea
Although ∆9 – tetrahydrocannabinol ( THC ), the only psychoactive component in cannabis, is effective in reducing the nausea and vomiting associated with chemotherapy treatment, the anti – nausea effects of combining THC with other components from
Measuring postural transitions using wearables
Postural transitions i.e. the way which we stand up or sit down are complex motor tasks that can be used to measure physical function. Currently these transitions, which can be classified as sit-to-stand (SiSt) or stand-to-sit (StSi),
