Yearly Archives: 2017
Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade
Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,
Fingernails – a window into the world of disease
If our eyes are the windows into our soul, our fingernails can be viewed as windows into our health. The finger nail plate and its surrounding supporting structures (the fingernail unit) (Fig. 1) is an often overlooked
Growing-up in a stressful environment affects the levels of glutamate in the hippocampus in adult depresses subjects
Mood disorders are emotional disturbances consisting of prolonged periods of excessive sadness, excessive joyousness, or both. Exposure to harsh parenting practices or to maltreatment during childhood can increase individuals’ vulnerability to mood disorders and the severity of
Fish migration: a simple mathematical description
Diadromous fishes migrate between rivers and seas, and are key drivers of surface water ecosystems and food webs. Analyzing migration of diadromous fishes is therefore a core for assessment of surface water systems from both biological and
The arms really can give the legs a helping hand in rehabilitation of human walking
The emergence of upright, bipedal walking is a characteristic of human evolution that separate us from our quadrupedal cousins—other animals. The upright walking posture freed our hands so that we could perform skilled tasks like signaling, carrying,
Grafting stem cells in 3D arrays
Neural transplantation has continued to show promise as an effective treatment option for neurovascular, traumatic and neurodegenerative disorders. Previous work in neural stem-cell transplantation has demonstrated the ability of distinct neural cells to repair damage and to
4th International Conference and Expo on Computer Graphics & Animation. Berlin, Germany. September 25-26, 2017
Computer Graphics & Animation 2017 welcome all to its 4th international conference during September 25-26, 2017 at Berlin, Germany. We cordially invite all the participants who are interested in sharing their knowledge and research in the arena
Crosstalk between gut, brain and metabolism in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS), the most common endocrine disorder of women in childbearing age, is characterized by hyperandrogenism, oligo-anovulation and polycystic ovaries in ultrasound. Obesity, a global epidemic, generally accompanies PCOS; but the link between these two
Past, present and future management of low-lying rectal cancers
In recent decades, great strides have been made in the management of the hardest to treat rectal cancers. If diagnosed with a low rectal cancer in the 1970s or 1980s, it was likely that after surgery the
Female pattern hair loss, biological ageing and the Leiden Longevity study
People age at different rates and individuals with the same chronological age vary widely in terms of health and function. Biological age describes the difference between the population cohort average life expectancy and the perceived life expectancy
Pancreatic incidentalomas: is laparoscopic approach safe and feasible?
Pancreatic incidentaloma is an asymptomatic incidentally lesion detected on a radiologic imaging performed for unrelated indication. This definition has been proposed for adrenal mass but actually the term is used for asymptomatic masses discovered in different solid
Viewing more than the tip of the iceberg: speech therapists learn to report on the whole of the swallow!
When we take a sip of our well-deserved cup of tea, it travels through our mouth, into our throat, passing our closed airway, through our food pipe and into our stomach. This process takes approximately 10 seconds.
Proteins regulate cancer cell attachment
Aggressive cancer cells are able to leave their original site and invade other tissues. In order for these cells to do this, they must have some way of moving around. This means that a cancer cell must
Are Internet lifestyle products counterfeit? A consumer-based survey
The use of lifestyle products has increased over the last few years particularly with the change in the social behaviour of individuals and the ease of access of medicines via the Internet. Lifestyle products can be of
New morphology of amyloid fibrils
It has been shown earlier that one of the proteins from the Saccharomyces cerevisiae cell wall (glucantransferase Bgl2) forms amyloid structures after isolation from cell wall under acid pH conditions. It is known that the acid treatment
Blue nevus of the uterine cervix – a melanocytic lesion corresponding to cutaneous blue nevi
Blue nevi are benign melanocytic disorders, which commonly present cutaneous lesions and rarely arise in female genital tracts. To date, although several cases of endocervical blue nevi have been reported, their biological nature is not sufficiently clarified.
Aldosterone enhances the magnesium permeable ion channel, TRPM7
The homeostatic regulation of salt (sodium) and water are basic functions of all organisms. In mammals, hormones such as aldosterone regulate the excretion and retention of water, sodium, chloride, potassium, calcium, and magnesium within the kidneys. Special
Menthol strengthens nicotine rewarding effects
Menthol is a monocyclic terpene alcohol that exists in plants of the Mentha genus. It is commonly known as mint. Menthol is a significant flavoring additive in tobacco products. Menthol-labeled cigarettes account for approximately one-quarter of the
Stanford team brings quantum computing closer to reality with new materials
Quantum computing could outsmart current computing for complex problem solving, but only if scientists figure out how to make it practical. A Stanford team is investigating new materials that could become the basis for such an advance.
An organic gas instead of inorganic gases for the enhancement of 129Xe magnetic resonance signals through optical pumping
Several new methods have been developed in these two decades in nuclear magnetic resonance (NMR) spectroscopy, which make us accessible to weak signals hitherto unmanageable because of the low sensitivity. Among them, spin-exchange optical pumping (SEOP) can
