Yearly Archives: 2017
Arsenic´s different effects under normoxia and hypoxia and its ambivalent role in cancer
Arsenic (As) is as natural contaminant in drinking water in particular in Argentina, Canada, India, Japan, China, Taiwan, Mexico, Chile, and the United States. It is best known as a toxic element which upon chronic ingestion is,
Let-7b expression in breast cancer: does have any implications on the DNA repair capacity?
Epigenetics study the changes on gene expression that occur without altering the primary structure of the DNA. Examples of epigenetic mechanisms that can produce such changes include microRNA ( miRNA ) silencing, DNA methylation, histone methylation, among
Oocyte activation and latent HIV-1 reactivation: AMPK links the creation of all human life and the potential eradication of HIV-1
In an active area of research known as HIV-1 cure research, the purposeful reactivation of latent/dormant HIV-1 in memory T cells, which induces death of the infected cell or alerts the immune system to the presence of
Inflammation was regulated by polyacrylic resins in human gingival fibroblasts
Temporary fixed prostheses are an important adjunct because they protect prepared teeth and prevent exposure of dental tissues. The most commonly used temporary restorative materials in prosthodontics are PMMA, MMA, and the more modern bis-acryl composites. The
Novel ROS1 mutations reveal a predictive mutational model for TKI sensitivity
In tumors with tumor-specific genetic alterations (i.e. 20-40% lung cancers), cancer cells are highly dependent on the function of a single oncogene, defined as ‘driver oncogene’ for their proliferation and survival. Many oncogene alterations have been identified
Occupational exposure to new influenza virus that infects cows
Influenza D virus (IDV) was first identified in 2013, and since been found in cattle and swine with influenza-like illness in multiple countries. It is closely related to influenza C virus but cannot exchange genes with influenza
Mangrove propagule size and oil contamination effects: does size matter?
Mangroves thrive in sheltered locations of intertidal zones of tropical and subtropical regions and are highly vulnerable to oil spills. Oil penetrates the soft mangrove sediments and coats aerial breathing roots. This leads to oxygen deficiency, suffocation,
Stage IVB cervical cancer: performance status and pretreatment WBC count are significant negative prognostic factors
Cervical cancer remains the second most common cancer among women worldwide and is a significant cause of cancer-related mortality in women. By the International Federation of Obstetrics and Gynecology (FIGO) classification, stage IVB cervical cancer is defined
The risks of brain damage after hyperthermia
This article describes the unintended neurological consequences after a period of fever or hyperthermia. A fever may have many causes, including after strenuous exercise, being in a heatwave, taking certain drugs and medications, and various illnesses. Hyperthermia
The groundwater quality assessment of Fars province, Iran
Groundwater is an important supplier of irrigation and drinking water, and it has a strong impact on rivers and aquatic ecosystems. In the developing countries like Iran, 80% of all diseases are directly related to poor drinking
MRI with GBCAs – Practical help to ensure patient safety
Malayeri et al writes: “At present, there is no evidence suggesting that gadolinium deposition in the brain alters neurologic function”. Where is the evidence for this statement? Free gadolinium is highly toxic. Even though no clinical implications
Inflammatory bowel disease (IBD) 2017: sorting out calls for inflammation
For its structure and function, the human gut can be considered as a barrier hub wherein the outer environment (comprising the huge antigenic contents of the gut microflora – the well-known microbiome populating the gut lumen with
Targeted nanoparticles for molecular imaging
Oncologic, cardiovascular, and neurological diseases are the most common causes of death in the developed world. It is well established, especially for cancer that early diagnosis results in more favorable outcomes. Although various diagnostic tests are available
Eat your carrots – otherwise your risk of getting Alzheimer’s might increase!
Vitamin A is an important component of human nutrition, delivered by e.g. liver or fish dishes, but also fruits and vegetables, such as carrots. It is not only needed for development of organs and tissue (e.g. the
Teasing apart the roles that oncogenic miRNAs play in breast cancer
Oncogenic miRNA and breast cancer Since the early 2000’s, the field of RNA has been contributing to major discoveries in cancer research. McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. Normally,
EGCg-AuNPs Nanotherapeutics – as an alternative Green Nanotechnology approach for treating cardiovascular diseases
Cardiovascular diseases are the leading cause of morbidity and mortality in the United States and globally. However, despite remarkable technological advances, significant limitations remain in stent-based treatment. Therefore, it is important to develop selective and effective therapeutics
Levosimendan to reduce mortality in cardiac surgery (CHEETAH trial)
Over the past decade, there was a significant decline of mortality after cardiac-surgery. Although the average perioperative mortality for elective procedures currently is 1% to 2%, the rate of major complications remains high. Low-cardiac-output syndrome (LCOS, a
Cellular migration required for testis development
Gonad development requires the integration of multiple cell types of various origins. Testis development in particular depends on the crucial step of vascular endothelial cell migration from the mesonephros (the embryonic kidney) into the neighboring gonad tissue.
A multistep virtual screening approach to identify proteasome inhibitors
Proteasome plays a fundamental role in the protein turnover by degrading misfolded, abnormal or damaged proteins, previously labeled through addition of a polyubiquitin chain. An aberration of this proteolytic system could result in different types of hematological
Could low albumin be a marker of an undiagnosed cancer?
Cancer is an increasingly common problem that affects one-in-two British people over the course of their lifetime. Survival rates are getting better with increased awareness, better tests and more effective treatments, but the UK still lags behind
