Monthly Archives: August 2020
The protein TMEM147 is a novel regulator of cholesterol homeostasis in human cells
In terrestrial vertebrate animals, cholesterol is a major sterol lipid with multiple, critically important biological roles. In cells, it is a key constituent lipid of the plasma membrane, affecting its fluidity and stiffness and acting as an
EEG reactivity in coma
The electroencephalogram (EEG) is a test of brain activity applied on Hospital Intensive Care Units (ICUs) to detect seizure activity, with up to half of ICU patients having seizures associated with their neurological condition. For this reason,
Epigenetic phenotype diversification helps animals to adapt to changing and new environments
There is increasing evidence that epigenetic phenotype variation can contribute to environmental adaptation, speciation and evolution. Epigenetic changes of the phenotype are caused by differences in gene expression rather than by alteration of the genetic code. Epigenetic
Effect of synergism of small molecules against fibrillation process of human serum albumin
There are different ways by which small molecules interact with protein and its aggregates. One of it is synergistic interaction of drugs or small molecules against protein aggregates. Protein aggregation is a common cause of neurodegeneration. Most
Reprogramming skin into brain to study aging and age-related brain diseases
“Inevitable as the passing of time” is a common phrase and a simple truth; in our lives, we may have impactful experiences, grow and learn but, inescapably, we age. It is clear that as we age, our
How can we remove radioactive Cs from nanosheet edges of clay in soil environment?
There has been steady progress in the decontamination work of radioactive Cs originating from the Fukushima Daiichi Nuclear Power Plant accident of Tokyo Electric Power Company in 2011. According to the Ministry of the Environment, Government of
Adverse Drug Reactions: power, harm reduction, regulation and the ADRe profile
Patients should be checked systematically to ensure that they are not being harmed by their medication. Through case studies of prescriptions of antipsychotics to older adults in the UK, we have shown that if healthcare professionals systematically
Trends in heart failure diagnosis for women and men in urban and rural settings in Ontario
Heart failure remains a significant cause of death and disability for women and men. It is estimated that 1 in 5 individuals will be diagnosed with heart failure in their lifetime, with an average survival of approximately
Any cell organelle can be the starting point for toxicant and pathogen-induced cell death
Toxicants and pathogens often induce death of their target and host cells. In order to investigate the different ways they can achieve this I have used the hepatopancreatocytes of decapod crustaceans as an example, Specifically, I tried
