Author Archives: karen
In vivo 2-color multiphoton imaging of genetic reporter fibroblasts in the skin
Fibroblasts are cells that synthesize collagen and support the maintenance of connective tissue in the skin, tendons, and joints. They maintain a critical role in the immune system’s response to tissue injury by promoting wound healing at
Protein structure detection in intermediate-resolution cryo-EM maps using deep learning
Cryo-EM has established its position in structural biology as an indispensable method of choice for determining macromolecular structures due to recent technological breakthroughs. The recent years have observed a steep increase of biomolecular structures solved by cryo-EM,
Prediction of thermal damage of three-dimensional bio-tissues in moving laser therapy
The thermotherapy is a useful approach in medical field, such as hyperthermia, laser soldering, laser ablation, laser surgery and other thermal treatment methods. In order to maximize the therapeutic efficiency while ensuring the patients’ safety, the thermal
Bayesian sparse neural networks for biomarker discovery with omics data
Recent advances in high-throughput biotechnologies, such as microarray and sequencing technologies, have provided an unprecedented opportunity for biomarker discovery, which potentially enhances the development of precision medicine. From a statistical point of view, the discovery of biomarkers
Preventing over-treatment in euthyroid patients with thyroid hormone abnormalities
Up to 12% of the U.S. population will be diagnosed with a thyroid condition. Because thyroid hormones affect every cell in the body, hypo- (low) and hyper-(high) thyroidism can be difficult to distinguish from other medical conditions.
Using AI to improve the quality and quantity of hand washing in hospitals
Poor quality hand hygiene has been identified as the main contributor to the spread of hospital acquired infections. In the USA, they affect 2 million patients of which nearly 90,000 die. The cost of these infections is
The noxious effects of benthic diatoms on marine invertebrates
Diatoms dominate various marine and freshwater environments, at any latitude, and are responsible for up to 25% of primary production. They may be either free-living in the water column or produce benthic biofilms. Studies on the chemical
How to Land a Job in Big Tech
Tech industry jobs often provide the types of salary and benefits that allow you to build a comfortable life. Some companies go above and beyond. Compensation, benefits, stock buying programs, and the prestige of having their name
Carica papaya loaded PVA-Gelatin nanofibrous scaffold: a wound dressing material
Every year millions of people worldwide encounter mishaps that may arise from burns, surgery, accidents, or chronic diseases compromising the skin’s integrity. These incidents can either result in lifelong functional impairment of the affected part of the
Aflatoxin exposure: pending regulation for vulnerable people
Mycotoxins are toxins produced by filamentous fungi in food, especially because of water stress in the field or inadequate humidity and temperature in storage. Mycotoxins produce a toxic effect on animals and humans, from acute effects to
Mesalamine for the prevention of recurrent diverticulitis?
Recurrent diverticulitis represents a relevant clinical problem, involving up to a quarter of patients after the first episode of diverticulitis. Unfortunately, there are no evidence-based data that indicate a targeted therapeutic approach for the prevention of recurrent
Soft-particle gel electrophoresis
Particle electrophoresis in free solution or in gel media is a powerful technique for characterizing the surface properties of colloidal particles. Particle gel electrophoresis, that is, transport processes of colloidal particles in polymer gel media under an
Developing aptamers and 21st century skills through innovative course-based aptamer research
Among the growing list of aptamer applications, innovative aptamer Course-Based Undergraduate Research Experiences (CUREs) have merged the scientific demand of aptamers with the positive student outcomes realized through authentic research experiences. This demand for additional aptamers is
Sheath blight of rice: challenges and management
Rice (Oryza sativa L) is one of the most widely consumed cereal crops, grown in more than a hundred countries. Around 40,000 different varieties of rice exist in the world, with China producing the largest amount of
Cryo-electron microscopy in drug development
Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for
TMEM165; The Bermuda triangle of glycosylation and Golgi Mn homeostasis
During evolution, eukaryotic cells have acquired a complex network of endomembranes delimiting distinct organelles with specific cellular functions. In mammals, the rough endoplasmic reticulum (ER) and the Golgi apparatus are two key organelles of the secretory pathway
Strong primary healthcare may reduce mortality
Healthcare is variably organized across the world. In some places, people attend medical specialists such as cardiologists and urologists directly. In other places, people attend primary care physicians for most health problems and, if necessary, they refer
Global climate change and mental health
In the past decade, several empirical studies and systematic reviews of the literature have documented the mental health impacts of global climate change. However, the range of impacts and their relationship to specific forms of climate change
Atmospheric and genetic parameters influence Rhinovirus transmission
Rhinoviruses are a diverse set of very small and common viruses, repeatedly infecting humans in the course of a single year. For most people, infection usually results in mild common cold symptoms, and spontaneously resolves without the
Botulinum toxin and occupational therapy for Writer’s Cramp
Dystonia is a neurological disorder characterized by abnormal postures that interfere with making movements. Writer’s cramp is the most common type of dystonia involving the upper extremity. Patients initially experience painless loss of control while writing, discomfort
