Category Archives: Research
Natural history of spinocerebellar ataxias
The spinocerebellar ataxias (SCAs) are autosomal, dominantly inherited progressive ataxia disorders. More than 35 genetically different SCAs have been defined. The most common, SCA1, SCA2, SCA3, and SCA6, which together affect more than half of all families
Bioinspired photocatalyzed Alkyl/Aryl thiosulfate transformation for drug modification
Aiming to conserve energy and reduce emissions, chemists have been trying to mimic the complex photosynthetic process of plants in relatively simple chemical ways, such as photocatalyzed reduction of carbon dioxide and solar-driven splitting of water into
A tutorial on randomized study designs for lifestyle interventions
Unhealthy lifestyle behaviours such as an unhealthy diet, excessive energy intake, smoking, excessive alcohol use, physical inactivity and poor stress-coping behaviour can act as causal factors in the pathway of many diseases. There are various types of
New study of robot faces helps resolve debate over “Uncanny Valley”
Roboticists are building some amazingly human-like robots these days, but many of us have had the unsettling experience of glancing at one of these marvels of modern technology only to find our skin crawling with revulsion. In
A new avenue in an effort to minimize injuries from acute myocardial infarction
Reperfusion therapy is currently the mainstay of acute myocardial infarction treatment; it salvages myocardial cells from ischemic cell death. However, abrupt restoration of coronary blood flow induces another type of cell death, called “lethal reperfusion injury”, which
What is the value of missing information when assessing decisions that involve actions for intervention?
Most decision support models in the medical domain provide a prediction about a single key unknown variable, such as whether a patient exhibiting certain symptoms is likely to have (or develop) a particular disease. However we seek
Does habitual Internet use affect our brain? Are both genders in danger?
The Internet has not only become our external memory and essential media source for social life and entertainment, it also has full potential to become addictive. Even though it is still a matter of discussion whether Internet
HIV-1 pathology: when metabolism meets immunology
“We are what we eat” To this day, the human immunodeficiency virus type 1 (HIV-1) infection is still a public health problem with more than 33 million affected people worldwide with a growing number of cases. Immunology
The Keepers of the Ring
Just imagine that you are driving and have a flat tire. Would you find it logical that the design of your car does not allow you to place the jack inside the car trunk? This is exactly
A new pluripotent building block for the synthesis of fluorine-containing functional molecules
Fluorine, which is represented by symbol F, is the most electronegative element (fluorine 4.0 vs. carbon 2.6, nitrogen 3.4, and oxygen 3.4): this means that fluorine strongly withdraws electrons from neighboring atoms. The introduction of fluorine or
Deposition of aluminum and iron in benign bone tumors (exostosis)
An exostosis is an outgrowth of new bone from the surface of a bone into the muscles; it is a frequent benign tumor in children. An exostosis causes discomfort and chronic pain, depending on its size and
Why food preparation is important
Plant foods such as fruits and vegetables are full of beneficial plant chemicals – phytochemicals – that can be lost during cooking. Water soluble phytochemicals, such as cancer-preventing glucosinolates from members of the cabbage family and phenolics
Muscle activation patterns after anterior cruciate ligament injury
The anterior cruciate ligament (ACL) is an important ligament in the knee joint. An injury to the ACL typically occurs during dynamic sports activities involving rapid changes of movement direction or landing from jumps, such as basketball,
Use of antibiotics in animals and people – resistance transfer
There is a great debate going on in the European Union and the United States, regarding the effects of the use of antibiotics in animals and the potential transfer of resistance to man, primarily via the consumption
Floating electrodes to manipulate small-gravity particle samples in modern microfluidic systems
Many biological samples such as bacteria and biomacromolecule are of negligibly small gravity due to their submicron size. To flexibly manipulate small-gravity particle samples dispersed in liquids is a challenge that has vexed researchers for years. But
New separation principle of proteins by liquid chromatography resulting in ultrafast high-resolution separation
The purpose of separation science is to isolate some useful substances from natural and/or synthesized products to serve for human society. An ideal separation method is to have the feature of “three high” of high resolution (quality),
Dental problems in a lesser dwarf lemur
Even non-human primates suffer from dental problems. In lemurs, teeth might crack due to especially hard food items like certain nuts, but also sugar contents in artificial diets or gingival lesions caused by hard food insects favor
Net Spin Transfer in Polymer Depolymerization
Depolymerization plays an particularly important role in the synthesis of novel macromolecule materials form recycled monomers, but it could also be influenced by multiple factors, especially the experiment conditions which makes analysis difficult to the polymer depolymerization.
A simple chemosensor for naked-eye and fluorogenic detection of cyanide
Cyanide (CN−) is one of the most lethally toxic chemicals to the living environment. However, CN− is widespread in industrial processes, such as gold mining, metallurgy, electroplating, and the synthesis of nylon, fibers, and resins Thus, it
The growing number of resistance traits may limit the number of efficient antibiotics
Antibiotics are one of the major medical innovations of the 20th century. However, due to the escalation of multi- and even pandrug resistance in human clinical isolates, mainly in bacteria such as community-acquired Enterobacteriaceae and nosocomial Gram-negative
