Tag Archives: oxidative stress
Blockade of estrogen receptor alpha mitigates alcohol-evoked myocardial dysfunction in female rats
Recent evidence challenges the longstanding view that light-to-moderate alcohol drinking might confer cardioprotection, and the latter is mostly based on population studies in men or in male experimental animals. However, while the reduction in blood pressure caused
Understanding the rare disease alkaptonuria: the role of oxidative stress, inflammation and amyloidosis
Alkaptonuria (AKU) is an ultra-rare disease that was recognized among the first inborn errors of metabolism. In AKU, an altered activity of the enzyme homogentisate 1,2-dioxygenase (HGD) occurring upon gene mutation lead to a defective metabolism of
Changes in 3-dimentional chromatin structure as a mean to relieve oxidative stress?
DNA in our cells is packaged into a structure called chromatin, which is mainly a protein-DNA complex. Chromatin needs to be loosened for fundamental processes to take place, such as decoding genetic information (i.e. gene expression) and
Cerium fluoride nanoparticles protect cells against oxidative stress
Nano-biomaterials engineering is one of today’s most promising areas of materials science. In very recent years, nanocrystalline cerium oxide (nanoceria) has been shown to possess enormous biological activity, which originates from its ability to scavenge the reactive
Withaferin-A, a phytochemical, has potential to reduce liver injury due to acetaminophen overdose
Acetaminophen (APAP), also known as paracetamol, is the most popular over-the-counter drug used for common illnesses such as head and body ache, cold and fever. When administered in therapeutic doses (≤ 4 grams/24 h for an adult),
ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration
Neurons, the major component of our brain, have long processes (called “axons” and “dendrites”) to communicate with other neurons and cells. In many brain diseases that old people get suffered from, such as Alzheimer’s disease, Parkinson’s disease,
Updates on the pathophysiology of systemic sclerosis
Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with autoimmune component, inflammation, and progressive fibrosis of conjunctive tissues of the skin and internal organs. Lung involvements are a major cause of concern as pulmonary fibrosis and
Metallothionein, oxidative stress and trace metals in gills of liver of fish species
Kuwait Bay is important area that is influenced by the local municipal and industrial discharges. Therefore, two types of local fish from were studies, yellow finned seabream which is pelagic fish swim between the surface and the
Physical activity and diet: the two pillars of hercules for health and wellbeing
News by the World Health Organization over the past few days claimed that eating too much red meat has been related to health adverse events including shorter lifespan, cardiovascular disease, and cancers. Remembering Paracelso aphorism: “Sola dosis
Nanocarrier-based antioxidant therapy: promise or delusion?
It has been well established that the damage produced by Reactive Oxygen Species (ROS), which are highly reactive molecules with an unpaired electron, plays an important role in a large number of human diseases. Because of this
NEIL2 repairs DNA damage within active genes, maintains chromosome end integrity, prevents inflammation
Mammalian cells are subjected to a plethora of exogenous and endogenous agents that cause damage to the cellular DNA. One of the major sources of such damage is oxygen-derived molecules and free radicals, collectively termed “Reactive Oxygen
Topical administration of an antimicrobial peptide as a new strategy for improved burn wound healing
Burn wounds represent a major global concern, as more than 100 million people worldwide are estimated to experience burn injuries every year. These may be caused upon exposure to heat, radiation, chemicals or electric shocks, often resulting
Mitochondrial ROS and cancer drug resistance
The repetitive and continuous circle of resistance to anti-cancer agents was a primary focus of the above-titled articles recently published in Pharmacological Research. Gaining a basic understanding of why so many (possibly all) drugs currently available against
Omega-3 fatty acids ameliorate age-related hearing loss
We have evaluated the effects of a diet rich in omega-3 fatty acids on age-related hearing loss using a mouse model. These mice present early hearing loss, the symptoms appearing normally at 4 to 6 months of
Psychological stress can influence key immune activities and an important protein in the response to infection
The central role played by our immune system is to protect us against infections. In doing so, the immune response creates a localized toxic inflammatory environment that makes it difficult for the infectious agent to survive. In
Why food preparation is important
Plant foods such as fruits and vegetables are full of beneficial plant chemicals – phytochemicals – that can be lost during cooking. Water soluble phytochemicals, such as cancer-preventing glucosinolates from members of the cabbage family and phenolics
