Tag Archives: biomarkers

A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis

Model of MCP-1 action in breast cancer cells

Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various

Crossing borders to accelerate diagnosis of neurodegenerative diseases

Steps in biomarker development process

Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial

VMAT2: a novel biomarker for myopia

Myopia, with increasing prevalence and earlier age-of-onset, is the most common eye disease in the world. But its etiology is still unclear. Lots of studies have confirmed the hypothesis that dopamine (DA) is one of the important

Negative regulators of cell death signalling pathways in cancer

Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such

Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer

Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are

The role of genetic polymorphisms as biomarkers for HCC risk in Caucasian population

Hepatocellular carcinoma (HCC) is a frequent malignancy in many regions of the world, and the second leading cause of cancer-related deaths. Incidence and mortality are dramatically increasing in USA and Europe. The major risk factors for HCC

A novel biomarker for oral cancer

Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked

Increased blood immune regulation in autoimmunity?

Through centuries, the immune system evolved to become highly proficient in protecting the human body from invading threats. Part of its strength relies on antibodies produced within germinal centres (GC). These structures form intricate networks of immune

Measuring small molecules for nutrition research?

Metabolomics is the study of small molecules that are present in biological samples. These small molecules include amino acids, fatty acids, organic acids and sugars, and are referred to as metabolites. These metabolites reflect the downstream activity

9th World Biomarkers Congress. Madrid, Spain. December 07-08, 2017

World Biomarkers 2017 is organized around the theme: “A New Era of Diagnosis and Clinical Research”. World biomarkers, in the hands of clinical investigators, provide a dynamic and powerful approach to understanding the spectrum of diseases with

10th World Congress on Biomarkers & Clinical Research. Baltimore, USA. October 18-20, 2017

Conference Series Ltd Conferences invites all the participants across the globe to attend ‘10th World Congress on Biomarkers and Clinical Research’ during October 18 – 20, 2017 in Baltimore, USA which includes prompt Keynote presentations, Oral talks,

DNA methylation markers in colorectal cancer state-of-the-art

Colorectal is the fourth leading cause of cancer-related death worldwide. There were over 1.3 million new colorectal cancer cases worldwide, of which approximately 50% died as a result of the disease in 2012. Like all cancers, CRC

Fish responses to ocean acidification comes with a cost

Ocean acidification is currently recognized as a major threat to marine ecosystems and has become one of the fastest growing research fields in marine sciences. The excessive amount of anthropogenic carbon dioxide is making our oceans warmer

Hybrid 2d-nanomaterials in electrochemical immunosensing of clinical biomarkers

A key to develop nanodevices with high performance for biosensors applications is to explore advanced functional nanomaterials . Among these materials , 2D – based nanohybrids clearly stand out in the field of electrochemical immunosensors for clinical

Enrichment design accommodating the biomarker misclassification

Increased understanding of the mechanistic heterogeneity of diseases has brought us to the era of molecularly targeted therapies (MTAs) in clinical oncology. The MTAs block the growth of cancer cells by identifying and attacking specific biomarker pathways

Finding aroma clues in the human breath to diagnose diseases

History of human odor analysis in disease diagnosis The use of the sense of smell as an indicator of human disease probably originated with Hippocrates (circa 400 BC). Early medical practitioners recognized that the presence of human

Secret of cardiovascular diseases (CVDs) hidden in small molecules

Diagnosis and treatment of cardiovascular diseases (CVDs) are a great challenge for today’s medicine. It also results from not fully explained pathomechanisms underlying their development and progression. The group of CVDs is a very complex mixture of

Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers and blood pressure

Disease of the heart and blood vessels (referred to as cardiovascular disease (CVD)) is the primary cause of death worldwide. A key public health recommendation for reducing the risk of developing CVD is to lower our intake of

Disregarded drivers of diversity within tumors

The past decades of cancer research have uncovered the staggering extent and widespread prevalence of intratumor heterogeneity, which refers to the differences between the genomes of cells in a tumor. In theory, each cancer arises from a

Spectroscopic platform to cut time and resources needed to quantify cancer cell biomarker concentrations

Survivability of a living cell, tissue and ultimately a being is influenced by the state of proteolytic degradation of extracellular matrix (ECM) components; if the dynamics of the degradation is perturbed, regulation of many biological processes such