Tag Archives: biomarkers
The use of olfactory neuronal precursors for antemortem Alzheimer’s Disease diagnosis
Alzheimer’s disease (AD) is a disabling and progressive illness that causes a high social cost and economic burden. Current diagnosis has been done by clinical appreciation based on the Diagnostic and Statistical Manual of Mental Disorders (DSM–5) and
Vaccine design in the OMICs Era
A retrospection into the field of vaccinology reveals the triumph of medical science over infectious diseases that were once a death sentence. Research on vaccines has come a long way since 1796 when Edward Jenner used a
Specific and non-specific biomarkers in neuroendocrine gastroenteropancreatic tumors
Neuroendocrine tumors (NETs) are a heterogeneous group of rare malignancies that can arise in almost all organs, although gastroenteropancreatic site (GEP) is the most common. Symptoms are rarely specific, and clinical manifestations may be evident only in
When toxicity goes circular: Isoprostanes as markers and effectors of oxidative stress
In normal conditions, there is a dynamic equilibrium between oxidants and antioxidants in the human body; however, when there is an unbalance in this redox state, oxidative stress occurs. In an unbalanced state, the peroxidation of polyunsaturated
Enlightening the importance of the NDRGs in the (cancerous) gut
The gastrointestinal (GI) tract is one of the most complex organs of the human body. With its approximate 5m length, a diversity of specialized epithelial cell types (the ‘lining’ of the GI tract), about 80% of our
Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation
Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the
A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis
Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various
Crossing borders to accelerate diagnosis of neurodegenerative diseases
Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial
VMAT2: a novel biomarker for myopia
Myopia, with increasing prevalence and earlier age-of-onset, is the most common eye disease in the world. But its etiology is still unclear. Lots of studies have confirmed the hypothesis that dopamine (DA) is one of the important
Negative regulators of cell death signalling pathways in cancer
Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such
Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer
Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are
The role of genetic polymorphisms as biomarkers for HCC risk in Caucasian population
Hepatocellular carcinoma (HCC) is a frequent malignancy in many regions of the world, and the second leading cause of cancer-related deaths. Incidence and mortality are dramatically increasing in USA and Europe. The major risk factors for HCC
A novel biomarker for oral cancer
Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked
Increased blood immune regulation in autoimmunity?
Through centuries, the immune system evolved to become highly proficient in protecting the human body from invading threats. Part of its strength relies on antibodies produced within germinal centres (GC). These structures form intricate networks of immune
Measuring small molecules for nutrition research?
Metabolomics is the study of small molecules that are present in biological samples. These small molecules include amino acids, fatty acids, organic acids and sugars, and are referred to as metabolites. These metabolites reflect the downstream activity
9th World Biomarkers Congress. Madrid, Spain. December 07-08, 2017
World Biomarkers 2017 is organized around the theme: “A New Era of Diagnosis and Clinical Research”. World biomarkers, in the hands of clinical investigators, provide a dynamic and powerful approach to understanding the spectrum of diseases with
10th World Congress on Biomarkers & Clinical Research. Baltimore, USA. October 18-20, 2017
Conference Series Ltd Conferences invites all the participants across the globe to attend ‘10th World Congress on Biomarkers and Clinical Research’ during October 18 – 20, 2017 in Baltimore, USA which includes prompt Keynote presentations, Oral talks,
DNA methylation markers in colorectal cancer state-of-the-art
Colorectal is the fourth leading cause of cancer-related death worldwide. There were over 1.3 million new colorectal cancer cases worldwide, of which approximately 50% died as a result of the disease in 2012. Like all cancers, CRC
Fish responses to ocean acidification comes with a cost
Ocean acidification is currently recognized as a major threat to marine ecosystems and has become one of the fastest growing research fields in marine sciences. The excessive amount of anthropogenic carbon dioxide is making our oceans warmer
Hybrid 2d-nanomaterials in electrochemical immunosensing of clinical biomarkers
A key to develop nanodevices with high performance for biosensors applications is to explore advanced functional nanomaterials . Among these materials , 2D – based nanohybrids clearly stand out in the field of electrochemical immunosensors for clinical
