Tag Archives: cancer

Computational systems biology in cancer brain metastasis

Cancer metastasis, especially cancer brain metastasis, is a complicated process representing the major cause for cancer-related deaths worldwide. A better understanding of the underlying mechanisms of such malignancies will enable us to develop more efficient therapeutic strategies.

How cells crawl… that’s right, crawl

Within our bodies, every cell must crawl – some only a few millionths of an inch, while others, like nerve fibers, must make their way from the spinal cord to the tips of our toes. The ability

Digital model of the cancer cell

We are postulating that human cells should be analyzed as analog/digital systems (biological computers) capable of digitalizing the analog information from the environment, processing that information in digital form and producing a programmed action according to that

Omega-3 fatty acids, obesity and breast density

Omega-3 fatty acids, abundantly present in fish oil products, are in large use among the public because of the widespread perception that they are able to ameliorate and even prevent many chronic diseases, including cancer. Our research

Cardiovascular disease burden in Hodgkin lymphoma survivors

In developed countries, lymphomas are the third most frequent tumors among the pediatric cancers following leukemias and central nervous system tumors. With substantial increase in survivors of Hodgkin lymphoma (HL), late complications of treatment have become extremely

The right tool for the right job – it is brain surgery after all!

Getting drugs into the brain to help treat cancer or neurological diseases like Parkinson’s or Alzheimer’s is pretty difficult. Generally speaking you can’t just take a pill or get an injection as the brain is protected by

Radiotherapy for prostate cancer: restrictions for the treatment of recurrent disease

Patients with prostate cancer who are treated with radiotherapy are not always cured. Depending on their pre-treatment risk factors (most importantly the stage of the tumour), they are at risk of recurrent disease. These recurrences often present

Radiotherapy in palliative treatment of metastatic NSCLC: not all one and the same

The role of an editorial is to incorporate the results of a new relevant study in the scientific scenario, shedding light on some particular results of the trial which can change the clinical practice. The starting point

Defeating cancer by taking advantage of its inbuilt frailties

The treatment of cancer is a conflicting and complex process; the drugs that are used to kill cancer cells are also toxic to your healthy tissues. However, the different physiology of tumors provides a route to deliver

Milk exosomes for drug delivery

The need to effectively deliver drugs to target site has employed a multitude of substances varying from biological to a chemical nature and solid metals for the preparation of tiny drug delivery vesicles called nanoparticles. However, factors

Side effects of radiation therapy: Why me?

Most lung cancers are treated with radiation therapy, often in high doses.  Although these treatments are absolutely required to prolong life (by killing the tumor or slowing its growth), radiation treatment can have negative side effects that

Evaluating methods for detecting deadly skin cancers

Melanoma is a rare, but potentially deadly, type of skin cancer that develops in skin cells called melanocytes, which are responsible for producing the pigment in your skin. According to the American Cancer Society, the probability of

Imaging tumor development using next generation raster scan optoacoustic mesoscopy

Cancer is one of the major diseases in the 21st century. Hundreds of billions of dollars have been spent on cancer research in the last half century, but still, our understanding of the disease mechanisms is limited.

A treatment option for laparoscopically-resected uterine leiomyosarcoma with morcellation

A new and frequently utilized treatment option for symptomatic uterine leiomyoma is laparoscopic resection with morcellation so the specimen can be extracted through a small abdominal incision or through the vagina. Despite meticulous preoperative evaluation , some

The genetic secrets of Uveal Melanoma

Uveal melanoma (UM) is the most common primary cancer occurring in the eyes of adults, with 1/100,000 new cases per year in the Western world. Most patients are between 60 and 65 years old. Although it is a

Importance of updating prognostic predictions: an example from breast cancer

Today prognostic prediction models are an integral part of clinical practice in many fields. They are typically used to access the risk of an event in the future after a well-defined starting point, for instance the risk

Risk modifier(s) of susceptibility to pediatric acute lymphoblastic leukemia

Acute Lymphoblastic Leukemia (ALL) is an acute form of cancer of the white blood cells, characterized by the overproduction and accumulation of immature precursors known as lymphoblasts. ALL is the most common type of leukemia in children

How antioxidants may have a pro-oxidant effect?

The main function of the consumption of antioxidants is to strengthen the activity of enzymatic antioxidant systems of our cells and this is intended to prevent or delay oxidative stress caused by the increase of reactive oxygen

Heart disease in cancer patients (onco-cardiology / cardio-oncology)

In the United States, heart disease and cancer have been the 2 leading causes of death from 1935 through 2013. In 2010, both diseases accounted for almost half of all deaths in the U.S. Notwithstanding, much success

Real life treatment of hepatocellular carcinoma: impact of deviation from guidelines recommended therapy

Primary liver cancer is one of the most common cancers at the global level. The outcome of hepatocellular carcinoma (HCC) is related to the extent of both tumor and liver disease, which influence the applicability and efficacy