Tag Archives: drug
Roots of risky decisions in drug dependence
Decision-making is a key activity of everyday life. Consequently, disturbances in the ability to make appropriate decisions or anticipate their possible consequences can result in massive social, medical, and financial problems. In the Iowa gambling test developed
A new drug to prevent vomiting from cancer treatment
Vomiting after drug treatment for cancer used to be a major problem. However 2 different types of drugs were introduced which reduced this vomiting. The first was ondansetron which was very effective for the vomiting which occurred
Silence the uncontrolled cancer cells’ growth by controlling cellular senescence
When toxic damage caused by environmental or internal stressors accumulates cells can either stop proliferation permanently ( cellular senescence ) or die. Cell death is a common goal of existing cancer therapies, yet cellular senescence is increasingly
Recharged autologous stem cells to combat cartilage defects in osteoarthritic patients
Inflammation is one of the greatest challenges for physicians and researchers working to find new strategies to regenerate patients’ damaged and deteriorated cartilage. Although humans have stem cells which can aid in many tissue repair processes throughout
3D environment enhance cellular capacities
Although we live under the 3D (three-dimensional) environment, drug testing is carried out usually by using isolated cells cultured under the 2D (two-dimensional) environment. Liver is a very important organ which metabolizes glucose, alcohol, lipids (e.g. cholesterol)
Receptors as drug targets
According to the latest count, human body has 37.2 trillion cells. They all have the same genetic material, half deriving from a sperm cell, the other half from an egg cell. Consequently, all the cells are in
Should you be taking a statin drug?
Millions of patients are currently treated with cholesterol-lowering statin drugs that are prescribed to prolong life and prevent heart attacks. For patients who have never had a heart attack or stroke (primary prevention), statin therapy is typically
Compounds from Australian Eucalypts: the next wonder-drug for cancer?
If there is one tree that every Australian can relate to, then it would be the none other than the Eucalypt. No wonder they are considered as the only trees that have the power to unite the
Isovaline, a compound first identified in the Murchison meteorite, shows potential for treating Epilepsy
Epilepsy is a brain disease that affects 65 million people worldwide and is characterized by seizures that arise from hyper-active and hyper-connected brain cells. Typically, the first approach for managing seizures is treating individuals with pharmaceuticals. However,
Using Anthrax toxin (Atx) for drug delivery
When people think of toxins in relation to medicine, they usually think of the use of the toxins’ warhead. This warhead has been used to kill things like cancer cells when directed by a cell-targeting antibody. However,
Nucleus-targeted anticancer drug delivery
Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. However, efficient nuclear drug delivery upon systemic administration remains a
A promising new drug treatment for Alzheimer’s disease
Diabetes is a risk factor for developing Alzheimer’s disease (AD). The underlying mechanism seems to be that insulin signaling in the brain of patients with AD is very much impaired. Insulin not only controls blood sugar levels,
Evaluation of colon specific tablets using experimental induced colitis rat animal model
Colon forms the important part of large intestine located after caecum. Compared to other regions of gastrointestinal tract (GIT), movement of material through colon is slow. Therefore a dosage form taken orally could take from as less
High blood pressure is controlled more effectively by two drugs in one pill
Hypertension, or high blood pressure (BP), is a major global public health problem, both because of how common it is and its correlation with cardiovascular disease. It has been identified as one of the major risk factors
How to optimize the effectiveness of anticancer therapy
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HCC is a public health problem worldwide because of its high incidence and its poor prognosis with high cancer-related mortality. In the majority of cases, patients
The drug that can inhibit infection by reovirus
Cellular diversity is, to some extent, determined by the molecules present within specific cells. For example, cells that make up the endothelium, the part of blood vessels that come in contact with blood, make specific proteins that
Metabolic regulation by the intestinal hormone FGF19: From basic science to clinical application
Physiological adaptations of our body to changes in nutritional status induced by fasting or food intake occur various times per day and are crucial to maintain a healthy metabolic state. To meet this requirement, our body is
Identifying doses in commercial liquid drugs sterilized by ionizing radiation
Drug sterilization with ionizing radiation, such as gamma-radiation using doses up to 25 kGy is a well-established technology, which can adequately eliminate bacteria by breaking down their DNA. This method is gaining ground due to its numerous
Can Beautyberry treatment improve the success rate of lung transplantation?
Ischemia/reperfusion injury is a type of organ damage that occurs when blood supply returns to the organ after a period of ischemia and a direct consequence of oxidative stress. It significantly contributes to the risk of mortality
Using Darwin to discover new advanced materials
The process of evolution, first described in detail by Charles Darwin, has resulted in the amazing diversity of plants and animals in our world, each subgroup shaped by the effects of the different environments in which they
