Monthly Archives: January 2018

Low-cost enrichment of datasets for genetic analysis: imputation and electronic health record linkage

The human genome consists of 3 billion base-pairs built from the nucleotides adenine (A), thymine (T), cytosine (C) or guanine (G). DNA sequencing is the process of reading and recording the nucleotide at each base in the

Quantum breaking of ergodicity in adiabatic electron transfer

The problem of ergodic vs. non-ergodic behavior alludes, generally speaking, to the following question: Can we deduce from a collective behavior of a large ensemble of noninteracting identical entities statistical properties of single individual objects entering this

The mechanisms of MCP-1 production in tumor microenvironments: Tumor cells are not home alone

When you look at tumors, you may think they are composed of 100% tumor cells. The fact is that tumor tissues contain not only tumor cells but also a variety of non-tumor stromal cells, including fibroblasts, endothelial

A “Cool” way to study Parkinson´s Disease

The Big Bang Theory left us amazed about how Leonard was able to bring back a snowflake embedded in resin from the North Pole to give to Penny. The reality is that this concept is not so

Pharma/Biotech Project Portfolio Management Masterclass. Singapore. May 8 – 10, 2018

The 3 -day, practical Biotech / Pharma Project Portfolio Management Masterclass Seminar is specially developed for Heads, Managers and Senior Executives of Biotechnology and Pharmaceutical Companies in charge of strategic planning and development, strategic marketing and business development, new product

How carbon monoxide interacts with the rutile titania surface?

Carbon monoxide (CO) and titanium dioxide (TiO2) are among the most studied probe molecules and metal oxide single crystalline supports in surface science, respectively. The variations in the adsorption infrared or ultraviolet-visible spectra of CO have been

Tapeworm-related cutaneous larva migrans is caused by a cysteine protease from the larvae themselves

The parasitic disease sparganosis is a form of cutaneous larva migrans and caused by larval tapeworms of the genus Spirometra. The life cycle of Spirometra includes two intermediate hosts, and adult worms parasitize the intestines of carnivorous

Coordination of DNA transcription and DNA replication by the DNA damage response through the Ddx19 RNA helicase

DNA transcription is a fundamental cellular process that allows gene expression through generation of messenger RNA molecules (mRNA) that are then translated into proteins in the cytoplasm of the cell. However when cells proliferate, another key cellular

Overcome obstacles in the treatment of scarred kidneys

More than 10% of the world’s population suffer from chronic kidney disease (CKD), a serious disorder that leads to a prominent reduction in quality of life and might end fatally. Independent of its initial cause, virtually all

Visualizing transcription factor dynamics, one molecule at a time

In a multicellular organism, each cell type expresses only a subset of genes encoded in the genome. Moreover, hundreds of genes can be regulated by external stimuli. This complex regulation is mediated by proteins called transcription factors.

Performing physiology outreach

Traveling to Australia and seeing its beautiful landscapes, friendly people, and exotic wildlife is a wonderful experience that creates lifelong memories. In 2015, I received a summer fellowship from my university which allowed me to make the

The road to new aortic valve disease treatment: Innovations in 3D models and drug delivery

Calcific Aortic Valve Disease (CAVD) resulting in aortic stenosis is a common heart disease that affects 25% of people over 65 years old, causing 17,000 deaths per year in the USA. The aortic valve regulates blood flow

What we know of evolution of the pelvis and walking upright

As children grow, the shape of the spine slowly changes from a C-shape in a newborn into a double-S-shape during adulthood. In the field of medicine, research has shown that the exact shape of this double-S is

Antibacterial substrate for wound dressing from waste products

It is now or never that we make use of our generated waste to produce valuable products. In this way, we can have closed loop recycling systems that can boost our economy. Chitin is a waste product

HspB1, a polypeptide sensor whose structure reacts to changes in the physiology and environment of the cell

The small heat shock protein HspB1 acts as an ATP-independent chaperone helping cells to cope with stress-induced aberrantly folded polypeptides. Other interesting properties of HspB1 are its constitutive expression in many unstressed human cells and its up

Vertebral asymmetry of the scoliotic spine

Scoliosis is a three-dimensional (3D) deformity of the spine, including lateral deviation in the coronal plane, as well as deformations in the sagittal plane and vertebral rotation in the transverse plane. Adolescent idiopathic scoliosis (AIS) is the

A novel synthetic approach to alternating peptides

Polypeptide with a repeating sequence has attracted particular attention as a promising candidate of innovative structural materials. Fibrous proteins such as fibroin, collagen, and elastin are the representative class among natural polypeptides with specific repeating sequence. For

IQ differences between right-handers and left-handers are negligible

How can we best approach the question of IQ differences between left-handers and right-handers? As with any scientific question, one should look at the scientific literature. Only there is an issue: when trying combinations of words, such

Effect of alpha-fetoprotein on lifespan of old mice

Alpha-fetoprotein (AFP) is one of the best-known embryo-specific proteins. It is primarily known as an oncomarker for tumors of the liver and gastrointestinal tract, but its antitumor effects have also been shown. AFP is the prevention of

Computational topology for biomedical image segmentation in pathomics

Topology concerns the study of fundamental and intrinsic properties of spaces which are invariant to continuous deformations, extrinsic evaluations or changes in magnitude e.g. scale, shape, distance, intensity, etc. Topology became an influential field of research by