Monthly Archives: December 2017

Pregnant women exposed to extreme temperatures relative to their usual environment may be at increased risk for having smaller babies

Common environmental factors such as extreme ambient temperatures and air pollution are known to increase the risk of many serious health problems including stroke, heart attack, asthma, and lung cancer. More recently, there is also evidence suggesting

Different perfusion patterns in a patient with acute ischemic stroke

The main goal of the current acute therapies for acute ischemic stroke is to restore perfusion in brain areas supplied by an occluded artery. The use of endovenous thrombolytic drugs and more recently of mechanical thrombectomy by

Computer simulations predict the cause of a drug’s fatal neurotoxicity in a failed clinical trial

A new drug called BIA 10-2474, in development for pain management, caused severe side effects in a clinical trial in France in 2016. In the safety phase of the clinical trial, one healthy participant died from unexpected

A selective AC1 inhibitor relieves pain

Adenylyl cyclases (AC) are proteins expressed throughout the human body. ACs have a central role in cellular and neuronal function. A number of different proteins and ions can interact with ACs and modulate their activity. ACs have

Watching caveolae under stress

The plasma membrane of many cells contain many protein-dense invaginations called caveolae or ‘little caves’. Caveolae are composed of ~140 molecules of caveolin proteins along with other components. Caveolae are thought to act like springs and flatten

Physical deformities in fruit flies on long term exposure to zinc oxide nanoparticles

Nano is a unit prefix meaning “one billionth, derived from Greek word nánnos means “dwarf”. The potential of matter at nano scale was given by Dr. Richard Feynman in his lecture “There is plenty of space at the bottom”. His idea

Selective intra-dinucleotide interactions and periodicities of bases separated by K sites

For testing neutrality or selectiveness in theories of molecular evolution, I decided to study the distribution of the two bases of a dinucleotide; the bases may be separated by 0, 1, 2 … K nucleotide sites. With

The relationship between cranberries ingestion and the reduction of the incidence of urinary tract infections

Urinary tract infections (UTIs) are common and are among the most frequent medical conditions requiring outpatient treatment. Approximately 80% of all UTIs occur in women, and 20% to 30% of women with a UTI will have a

Chronic myeloid leukaemia: a success story in cancer therapy

Chronic myeloid leukaemia (CML) is a haematological malignancy caused by a chromosomal translocation that places the c-ABL oncogene, normally located on the long arm of chromosome 9, under the control of the breakpoint control region (BCR) on

Acylation of soluble polysaccharides in a biphasic system catalyzed by a CE2 acetyl esterase

Acylated sugars attain altered or improved properties comparing to their native form and thus present great commercial significance due to the fact that they can be used in several applications, such as biosurfactants in biomedicine, foods, detergents

Molecular origins of convergence and uniqueness of protein structures!

Protein folding, tagged as an NP hard problem is the process by which a protein sequence acquires its biologically functional native structure, with a high-fidelity rate. Proteins are essential components of all body tissues, muscles and act

Tail regeneration in lizard is driven by key genes of the Wnt-pathway

The importance of lizards as models to analyze the process of organ regeneration is relevant since, differently from the classical amphibian models, these vertebrates are amniotes adapted to the terrestrial environment, therefore closer to mammals and humans.

When your medication backfires and calls in the wolves

Your immune system is like an army inside your body. It is constantly on guard to protect you against attacks from the outside, such as infections. It also protects you from attacks from inside, such as cancer

“I forgot what you thought” : theory of mind abilities in Alzheimer’s disease

“Theory of mind” or ToM is a critical aspect of what is called social cognition, a set of neurocognitive processes allowing us to have normal social interactions. Named because humans are assumed to make “theory” on other’s

Early pregnancy regulates Toll-like receptors expression in ovine trophoblasts and peripheral blood leucocytes

Interferon-tau (IFN-t), released from the embryonic trophoblasts, is the first embryonic signal in ruminants and drives the process of maternal recognition of pregnancy. It possesses critical functions such as regulation of prostaglandin secretion, conceptus elongation, immunological tolerance,

Anti-CD20 treatment shows changes not only in B-lymphocytes but also in T-subpopulations

In renal pathology, Rituximab has been proven to be useful in the treatment of some primary glomerulopathies, vasculitis with renal involvement, severe lupus with kidney disease, and especially in renal transplantation, where it is applied during the