Category Archives: Research
DIY materials will allow scientists and engineers to re-make the world
Human development has been based on making the best possible use of natural materials and resources – initially plants, wood, stone and metals, before the evolution of man-made materials such as plastics. All of these kinds of
Subjectivity and molecular brain topology
It has become increasingly recognized that something essential is missing in the traditional interpretation of brain signals if this builds solely on the computer-metaphor (‘the brain as a computer’). In the frame of so-called ‘neural field models’
Novel targets for neuroprotection in neonatal brain injury
Developing brain is highly susceptible to injury. Together, prematurity and hypoxic ischemic encephalopathy (HIE) account for 50% of global mortality and significant neurodevelopmental impairment in survivors. HIE is a clinically defined syndrome of disturbed neurologic function due
Acute ischemic stroke: Can clinical risk factors exclude more women than men from thrombolysis therapy
Acute ischemic stroke is the physiologic manifestation of lack of perfusion to the brain. This lack of blood flow may be secondary to thrombosis of a large vessel, an embolus from elsewhere that lodges into a smaller
Na/K pump mutations lead to hypertension by impairing Na+ and K+ transport
Aldosterone is a hormone that regulates blood pressure by increasing the amount of salt and water that your body retains as blood is filtered through the kidney. Aldosterone is produced by specific cells in the adrenal gland
One way traffic of wave propagations
Waves in waveguides can usually travel in both ways. When the conditions for coherent perfect channeling (CPC) are met, waves travel only in one way. The schematics of the three-waveguide system CPC are shown in Figure 1(a).
Emerging diversity of the CRISPR-Cas system in cholera phages
Interactions of bacteria and their phages, which are viruses hostile to bacterial survival lead to the evolution of numerous phage resistance mechanisms. CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated proteins) is such a defense system of bacteria. The
Organic synthesis provides 17,18-EpETE and isoleukotoxin diol in optically active forms
The epoxide ring opening of the trimethylsilyl substituted epoxy alcohol 1 (R1 = H) by CH3S(O)CH2Na (NaDMSO) produces anion 2 as the transient species, which undergoes an unusual reaction rather than the Peterson olefination (Fig. 1). When
Achieving synergistic biopolymer functions using systems chemistry
Biology succeeds by maintaining intricate networks of chemical and structural information far from equilibrium. The guiding premise of the highlighted manuscript1 asks whether synthetic and materials chemistry will be able to achieve a bottom-up construction of alternative
Amniotic membranes can ease the eye pain
The cornea is one of the most innervated tissues in the body. When the corneal nerves undergo damage from various causes (such as refractory dry eye, corneal burns and infections, refractive surgery, among others), abnormal nerve regeneration
How a cellular samurai may be linked to autism
Inside cells, a highly dynamic and ever-changing cytoskeleton network determines cell shape (permanent or temporary), powers movement (intracellularly or on a substrate), aids cell division and segregation of chromosomes in daughter cells, and supports cellular extensions like
Focal epilepsy in four generations of a 19th century family
Two main types of epileptic seizure disorder have been recognised for more than half a century. Generalised seizures begin in central areas of the brain and produce immediate loss of consciousness, sometimes with bilateral jerking or widespread
Glycans to reprogram the immune response
Glycans are structures composed of sugars or carbohydrates, which are highly abundant on all cells. These molecules serve many functions, including binding and communication between cells, movement of cells and maintenance of tissue structure. Glycans are crucial
Calf hemodialysate: nutritive value plus placebo effect
Highly purified calf hemodialysate (HPCH), known as Actovegin or Solcoseryl, has been proposed as a medication for certain neurological and other diseases. For example, Actovegin was reported to have beneficial effects on cognitive performance in patients with
Stem cells accept the degradation products of Poly (ε-caprolactone)
One of the serious health issues experiencing by humans in the world are accidental injuries and associated complications. Treatment strategies for these injuries are depending on their severity and age of the person gets injured. Among this,
The role of genetic polymorphisms as biomarkers for HCC risk in Caucasian population
Hepatocellular carcinoma (HCC) is a frequent malignancy in many regions of the world, and the second leading cause of cancer-related deaths. Incidence and mortality are dramatically increasing in USA and Europe. The major risk factors for HCC
Uremia. A history of urine in the blood
The term uremia was first introduced in 1847; literally translated, it means “urine in the blood.” Today, uremia describes the myriad of symptoms and organ derangements that result from the failure of the kidneys in its normal
Patient safety ward round checklist via an electronic app
Patient safety is the tentpole around which modern healthcare is built. Though awareness of shortcomings in safety checks in the medical community is growing, implementing systematic approaches similar to those utilized in other high reliability industries is
Endothelial stiffening: a new parameter of endothelial damage in athero-susceptible regions of aorta
Atherosclerotic plaques that clog major arteries and lead to heart attacks and strokes are known to develop in sites exposed to non-unidirectional disturbed flow, such as bends and branches, whereas arterial segments that are straight and exposed
Anti-tubercular peptides: Future puissant weapon for tuberculosis therapy
Tuberculosis (TB) is one of the oldest and deadliest airborne asymptomatic tropical diseases in the world, caused by M. tuberculosis (Mtb), infecting one third of the global populace. At present, the emergence of multidrug-resistant tuberculosis and extensively
