Category Archives: Research
Metformin and stem cells act synergistically to treat insulin resistance
One of the principle defects of type 2 diabetes is insulin resistance which is the inability of insulin to exert a biological action at the level of its target tissue viz. muscle, fat and liver. Metformin is
Fracking is fracturing the total environment of the Earth
Hydraulic fracturing (fracking) is often called high-volume (i.e., up to 5 million gallons of water) high pressure (i.e., 10,000 – 20, 000 psi) horizontal hydraulic fracturing, in which horizontal drilling technique is used to recover natural gas
Immune damage of Apical Epidermal Cap impedes limb regeneration in frog
The evolution of the immune system in terrestrial vertebrates has allowed a high efficiency in the protection against mutated and cancer cells, foreign substances and microbes. Immune cells however become fully immunocompetent only late during development or
Cleaning verification dilemma of manufacturing equipment: Can the analytical method validation fail due to the cleanliness of the stainless steel surfaces?
In the pharmaceutical industry, the majority of the non-disposable equipment is made of electropolished, stainless steel material. The cleanliness of non-dedicated equipment should be verified before subsequent release for use in the manufacture of other intermediates, active
Understanding vaccine development – Lessons to make effective vaccines against Alzheimer’s disease
A natural protective immunity against a disease usually anticipates the successful development of preventive vaccines; as shown by the infectious diseases and lately cancer vaccines. Currently available information shows that the immune system is since an early
Suvorexant, a dual orexin receptor antagonist, may work as a glucose regulatory switch
Glucose is the predominant metabolic fuel for the brain. Thus, the mechanism of glucose regulation is crucial to survival. Insulin is the main glucose regulatory hormone among redundant glucose regulatory factors. However, we found that suvorexant, a
Intrinsic human multidrug transporters as helpers against Alzheimer’s Disease
The cause(s) of Alzheimer’s Disease (AD) is still unknown, so is a proper method for diagnosis. AD is a widely occurring form of neurodegeneration that is considered to affect 47 million people worldwide, according to the World
We are what we eat, so do aphids
Many studies are currently done on the human microbiota, mainly because its relevance to medicine. Characterization of the human and mice microbiota diversity and their responses to stress conditions and association with a range of illnesses are
Over one-third of men report perpetrating sexual assault when hooked up to a fake lie detector
Across studies, approximately 15-20% of women report that, since adolescence, they have experienced one or more nonconsensual sexual acts perpetrated by a man through use of incapacitation, threats of physical harm, or physical force; researchers often label
New turtle fossils from Uinta Basin represent last documented members of the extensive Baenidae radiation
The baenid turtles were an extinct clade of North American freshwater river turtles with an extensive radiation spanning from the early Cretaceous (125 million years ago) to the middle Eocene (40 million years ago). More than 30
The broadened spectrum of Fitz-Hugh-Curtis syndrome
Fitz-Hugh-Curtis syndrome (FHCS) is a condition characterized by inflammation / infection of the liver capsule (perihepatitis) and adjacent peritoneal surfaces. It has, typically, been described in young women of child bearing age in association with either overt
New treatments for breast cancer
Now that 90% of women diagnosed with breast cancer will live at least 5 years, new treatments are aim at improving outcomes for the 10% who are not responding to current drugs and delivering treatments with less
Treatment for spinal cord injury
Approximately 20,000 traumatic spinal cord injuries (SCIs) occur each year in the United States. These injuries are often associated with paralysis and other permanent disabilities. SCI is now recognized to occur in two phases, described as primary
Innovative method for oriented and closed-packed immobilization of immunoglobulins
For enhancing the sensitivity of immunosensing techniques, both clustering and oriented immobilization of immunoglobulin G (IgG) on solid phase are crucial. Conventionally, IgGs have been immobilized onto solid phases (e.g., gold, silica) with variety of scaffold chemistries
L-arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation
Mediated by nitric oxide (NO), intact endothelial cells control vascular homoeostasis by regulating vascular tone and preventing smooth muscle cell proliferation, monocyte adhesion to the endothelium and platelet aggregation, thereby protecting blood vessels from the formation of
A quick, simple, effective screening test for concussion
Concussion is a real prospect in many physical contact sports and physically demanding sports. Immediately after a concussion the brain doesn’t act normally. Typical issues for a person with concussion are confusion, difficulty responding to emotional situations
Interrogating the genome: approaches and tools for accessing genomic databases
Reference genome DNA sequences for thousands of species have now been determined, and deposited in freely – accessible public databases. The availability of these genomic data has revolutionized biology, enabling insights into the evolution of life on
Distinct expression profiles of acyl-CoA-binding proteins AtACBP4 and AtACBP5 during pollen development
Flower development is a process during which plants must progress from sexual immaturity to maturity. Throughout these phases, the differential expression of many genes and proteins is evident. In angiosperms, the pollen generates male sperms to facilitate
Similar but ectopic factor in chloroplast biogenesis between dicotyledonous and monocotyledonous plants
Seed is one of the successful form of reproduction in evolutionary history of land plants. Compared to primitive plants (ferns, mosses and liverworts) which do not have seeds and require water to propagate themselves, seed plants now
Nanosensor for diabetes management
Diabetes is a major health concern for millions around the world. In addition to the analysis of free glucose level in blood, glucose bound to haemoglobin (HbA1c) is considered to be a very useful diagnostic marker for
