Substrate phosphoswitching: a novel way to regulate enzymatic activity by phosphorylation of its substrate
Cells sense a vast variety of signals by receptors that are distributed on their surface. This perception transduces internal physiological responses using signal pathways, a cascade of protein interacting to bring a change in the cell behavior.
Aspen fungal endophyte communities are enriched after herbivory by leaf eating Chrysomelid beetles
Aspen trees grow abundantly and extensively across the forests of the northern hemisphere. They are early succession species that can quickly establish after fires or storms, and they also support a high biodiversity. While the biodiversity associated
Apple cider vinegar can help clear bacteria and yeast infections; a natural cure
Antibiotic resistance poses a major health issue worldwide. There has never been a greater need for new anti-microbials which are natural, active on multiple organisms and ideally beneficial to the patient. Bacteria such as E-Coli, Staphylococcus aureus
Evaluation of a dialectical behavior therapy training model in residential programs
Dialectical behavior therapy is a cognitive theory-based intervention that has previously demonstrated effectiveness in treating a range of behavioral disorders. However, DBT can be challenging to implement in community-based settings. Little guidance is available on models to
Optimal level of membrane cholesterol guarantees the proper functioning of Kv channels
Cholesterol is the most abundant lipid of the mammalian plasma membrane. It is well known that cholesterol influences membrane biophysical properties and regulates the activity of multiple types of ion channels, including K+ channels. The reported mechanisms
GSK-3 beta: a therapeutic target for Parkinson’s disease
Neurogenesis is a process of birth of newborn neurons from neural stem cells (NSCs). It is a complex, multistep process which involves NSC proliferation, differentiation, migration, maturation and integration of newborn neurons into existing neuronal circuitry. Continuous
Making mountains out of molehills: how stem cells become platelets
You have 100,000 km of plumbing (blood vessels) in your body. What then keeps them from leaking? This essential work is carried out by tiny cells called platelets, which are able to form a plug to stop
Confirmation and testing of an idea of using mobile technology in heart failure
Heart failure means that the heart is not pumping blood as well as it should. The weak pumping function of the heart causes blood to back up into the blood vessels around the lungs causing cough and
The needs of carers of blood cancer survivors: are there differences between Australia rural and urban dwellers?
As cancer treatments are increasingly delivered on an outpatient basis, the burden on partners, relatives and friends or support persons increases. Such people play a critical role in helping cancer patients manage their care. This can take
Treatment of autoimmune blistering diseases during pregnancy
Autoimmune blistering diseases occur when one’s own immune system attacks the skin and mucous membranes (such as your mouth) forming blisters. This group of diseases including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid
Primary cilia: the story of the hair-like organelle that signals just became more complicated
Cells are the simplest functional unit of biological life. The basic components of cells are taught in biology classrooms across the globe, but despite being widely studied, cells still contain mysteries. Recently, scientists have rediscovered the existence
Ingredient in hops to treat learning and memory impairments and metabolic changes associated with a high-fat diet
Metabolic syndrome (MetS) is a risk factor for cardiovascular disease and type 2 diabetes. MetS is associated with enhanced risk to develop age-related cognitive impairments and and dementia. Diets high in saturated fat induce inflammation that contributes
Can EBI2 receptor protect brain cells (oligodendrocytes) from dying during disease?
The four major brain-specific cell types in the brain are: (i) neurons, which transmit and process information via electrical signals, (ii) oligodendrocytes, which insulate neuronal axons with fatty sheets called myelin to ensure fast and complete electrical
Bone microstructure and the size of your femur
Human bones are often thought to be static tissues because of their hard structure. However, in addition to mineral they also contain collagen. This combination gives your bones flexibility in adapting to exercise. Adult bones can respond
A simple system for comprehensive monitoring of o-chlorophenol
The o-chlorophenol is a typical chlorophenol that is extensively used in synthesizing fungicides, preservatives, herbicides, and insecticides. As a highly toxic, carcinogenic, and mutagenic substance that poses serious ecological threats, o-chlorophenol has been listed as a priority
8th Annual Pharma CI Europe Conference & Exhibition. Basel, Switzerland. March 5-6, 2019
The 8th Annual Pharma CI Europe Conference (March 5-6, 2019, Basel, Switzerland) is the best and largest assembly of competitive intelligence executives in pharma, biotech, and medical devices! This anticipated gathering of industry elites will feature a program
Kidney function decline in polycystic kidney disease – it’s not always off the cliff
Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common (estimated to affect 1 in 1000 to 1 in 4000 persons all over the world) inherited disorder that leads to kidney failure in the majority of patients
Unravelling the genetics of disease resistance and agronomic traits of spring triticale using wheat and rye genomic resources
Triticale is an important small grain cereal crop which suffers severe yield, grade and end-use quality losses due to Fusarium head blight (FHB) and ergot (ERG) diseases predominantly caused by the fungal pathogens Fusarium graminearum (Fg) and
Getting metals into mitochondria
Scientists consider mitochondria, an organelle within cells, as a power plant. But mitochondria are also a site for metallurgy. There iron enters heme, the compound that binds oxygen in hemoglobin and certain other proteins, or helps form
A tipping point in the size of human groups for successful cooperation in social-ecological systems
How large should be a human group to succeed in collaborating effectively? From a theoretical standpoint, social sciences teach that the larger is the group the harder is to cooperate. So far there was no convincing evidence
