Tag Archives: cancer
Biomarker panel for detecting early pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is the fourth leading cause of cancer-related deaths in the USA. Most of the PDAC patients are diagnosed at an advanced stage of disease and their
PREMM: A mobile application to drive your own hereditary cancer prevention
In the recent publication, ‘Community Practice Implementation of a Self-administered Version of PREMM1,2,6 to Assess Risk for Lynch Syndrome’, Dr. Luba and colleagues at the Monterey Bay GI Consultants Medical Group in Monterey, California, present the use
Oxidative stress sensitivity of cancer cells could be altered by plasma membrane status
Oxidative stress is defined as “A status that the balance between the oxidation reaction and the antioxidant reaction is lost in our body, and that the oxidation state is dominant.” Oxidative stress is generally adverse for our
What is a SERM and how does it work?
Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They
Transmitted sound wave mammography
This study was designed to look at a new type of totally harmless breast imaging called whole-breast transmission ultrasound to see if it could do something mammography cannot do – that is to diagnose the presence of
What it takes to survive a transplant
Many patients with blood cancers, such as multiple myeloma, leukemia, or lymphoma, have radiation treatment or chemotherapy to destroy their tumor cells and diseased bone marrow. Unfortunately the treatment damages their immune system leaving them immunocompromised. To
RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies
Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with
Too hard to defeat Devils
Hematopoietic cell transplantation (HCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). However, relapse following HCT is considerable and becomes a major cause of failure in patients with MDS and AML.
p53 gene reactivation reverts hypoxic resistance in KRAS mutant tumor cells decreasing glucose uptake
When growing distant from primary blood supply sites, tumor cells face hypoxia characterized by niches restricted in oxygen and glucose. Cells acquiring resistant to hypoxic stress undergo metabolic re – programming, and increased resistance to 3 –
A new extracellular role for miR-939 in triple negative breast cancer
Triple negative breast cancer (TNBC) is defined as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) negative breast carcinomas (BC). Unfortunately, this kind of tumor is characterized by poor prognosis, high
Simultaneous glucose fasting and autophagy inhibition enhances chemotherapy treatment
If you could cut your risk of developing cancer, diabetes, and heart disease, rejuvenate your immune system, and potentially live longer – would you do it? What if the answer to potentially save your life is as
Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types
Most cancers are driven by somatic mutations in proto-oncogenes and tumor suppressor genes. Genetic changes in a tumor may accumulate in the tissue self-renewal phase prior to neoplasm. The risk of sporadic mutations increases with age. In
Pancreatic cancer stem cells: fatty acid synthesis and mevalonate pathways are implicated in their survival
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high metastatic potential. The disease is the fourth leading cause of cancer-related deaths in the USA, and is projected to be the second one by 2030, due
New therapy for the treatment of childhood bone cancer
Cancer in children and young adults is rare, with survival rates being very high, mainly depending on the treatment. The biggest proportion of this diagnosis will be on leukaemia and brain tumours, with just about 3% of
International Conference on Oncology and Cancer Therapeutics. Chicago, Illinois, USA. October 30- November 01, 2017
Allied Academies invites all the participants from all over the world to attend “International Conference on Oncology and Cancer Therapeutics” held in Chicago, Illinois, USA at October 30- November 1, 2017 which includes prompt Keynote Presentations, Special
A novel mechanism by which viral integration drives cancer
Human papillomaviruses (HPV) are a group of about 200 DNA viruses that infect the skin, or the mucous membranes of the anus, genitals and oropharyngeal cavity. HPV infections are the most common sexually transmitted disease in the
Hospital readmission after head and neck microvascular reconstruction
Unplanned readmissions are associated with decreased healthcare quality and increased costs. This nationwide study examines causes for unplanned readmission among head and neck cancer patients undergoing immediate microsurgical reconstruction. Patients undergoing head and neck tumor resection with
Proteins regulate cancer cell attachment
Aggressive cancer cells are able to leave their original site and invade other tissues. In order for these cells to do this, they must have some way of moving around. This means that a cancer cell must
Prostate-specific antigen 1.5: The new screening protocol
Prostate cancer is the leading cause of cancer-related death in American men. Tragically, once the disease is spread beyond the prostate gland, therapies become very limited and survival is poor. Like other cancers, prostate cancer can recur
