Tag Archives: tumor
Small-molecule RETRA is effective against a fatal childhood cancer
The bone tumor Ewing’s sarcoma is one of the most aggressive cancers in childhood and adolescence. Before the era of chemotherapy, more than 90% of Ewing’s sarcoma patients succumbed to their disease. With the introduction of intensive
Silence the uncontrolled cancer cells’ growth by controlling cellular senescence
When toxic damage caused by environmental or internal stressors accumulates cells can either stop proliferation permanently ( cellular senescence ) or die. Cell death is a common goal of existing cancer therapies, yet cellular senescence is increasingly
Many factors determine prognosis in resected lung cancer. Is visceral pleural involvement one of them?
Prognosis after pulmonary resection for primary lung cancer is closely related to tumor stage, since stage predicts the risk recurrence. Lung cancer staging is based on the TNM system that evaluates tumor size and contiguous tissue infiltration
A functional immune system against cancer in breast cancer patients
One of the hallmarks of cancer development is the ability of tumor cells to evade the recognition by the host immune system. However, the presence of immune responses against cancer is frequently observed in cancer patients. The
Metabolism and pheochromocytoma/paraganglioma
Tumors are named according to the organ or the tissue whose cells undergo biological derangement causing the loss of the control mechanisms that normally limit cell growth. Therefore, breast tumors derives from the cells of the ducts of
Disregarded drivers of diversity within tumors
The past decades of cancer research have uncovered the staggering extent and widespread prevalence of intratumor heterogeneity, which refers to the differences between the genomes of cells in a tumor. In theory, each cancer arises from a
VIRTUOSO: Virtual clinical trials concept to help identify resistant tumors
The use of anti-cancer drugs (chemotherapy) is one of the standard-of-care therapeutic treatments routinely applied in clinics. However, a significant portion of patients who show a good initial response to the chemotherapeutic treatment become unresponsive to the
Punching above their weight: how the smallest RNAs offer great promise for cancer biology
In recent decades, scientists have witnessed transformative developments in the field of RNA biology. RNA molecules are similar in composition to their more famous DNA counterparts (they are both nucleic acids), but are present in a variety
Treating primary cardiac angiosarcoma
Radiotherapy and chemotherapy are usually reserved for inoperable patients or given adjuvantly for those with residual tumor and/or metastatic disease. Elsayad and coworkers describe a novel treatment modality with adaptive radiotherapy using tumor-volume tracking in a 37-year-old
Changes in anti-predator behaviour of prey after large predator declines
Large carnivores are suffering severe declines worldwide due to their vulnerability to habitat loss, emerging diseases and persecution. Their loss has been attributed to changes in the abundance and behaviour of other species, including small mammals and
Fully human anti-CAIX antibodies for RCC immunotherapy
Globally, there are roughly 270,000 new cases and 116,000 deaths attributed to kidney cancer occur each year. More than 90% of kidney neoplasms are classified as renal cell carcinoma (RCC), which accounts for 3% of all adult
Identification of a novel factor implicated in the resistance of cancer to the therapy
Therapeutic treatment of cancer involves radiotherapy and/or chemotherapy so to generate a large amount of lesions in the DNA. Because cancer cells have reduced capacity to repair DNA lesions and are unable to slow down proliferation, this
Surgery for pancreatic head cancer
Pancreaticoduodenectomy (PD) offers the only chance of long-term survival for patients with pancreatic head cancer. The procedure involves removing the pancreatic head together with the duodenum, gallbladder and most of the common extra hepatic bile duct (Fig.
Nonsteroidal anti-inflammatory drugs attenuate lung carcinogenesis in smoking female mice
Chronic inflammation plays a crucial role in the development of cancer in general and of cigarette smoke (CS) – related lung cancer in particular. Accordingly, anti-inflammatory drugs, among which the extensively used nonsteroidal anti – inflammatory drugs
Phospholipase A2 group IVc blocks mammary tumor apoptosis
The Hirosaki hairless rat (HHR) is a mutant rat strain with autosomal recessive inheritance spontaneously derived from the Sprague-Dawley rat (SDR). The hairless phenotype of HHRs is due to the deletion of basic hair keratin genes, and
A method for studying mouse mammary tumorigenesis
Metastasis is the last step of primary breast cancer progression in which cells from the primary tumor leave and go to other organs. Breast cancer cells often metastasize to the lung, among other organs. Each step in
How to improve outcome in patients with primary appendiceal mucinous cancer
Appendiceal mucinous cancers are extremely rare cancers. The management of mucinous appendiceal tumors is mainly based on single-institution experiences. A challenge in the treatment of this disease is that a large number of patients present with disease
Chloroquine inhibits the malignant phenotype of glioblastoma
Glioblastoma (GBM), the most common and aggressive primary brain tumor, is characterized by excessive growth and infiltration of the normal brain which prevents the complete surgical resection. These tumors also are refractory to standard treatment strategies, which
Palpable melanoma groin lymph node metastases
Melanoma is the most lethal type of skin cancer. In 2012 232,130 persons were diagnosed worldwide, and 55,488 estimated deaths occurred due to melanoma. Patients who present with a palpable lymph node metastasis in the groin area
Cancer connection: study of inflammation offers tantalizing clues
The body displays a remarkable capacity for healing wounds— a process we often take for granted. Within a day, a finger we’ve carelessly nicked returns to normal. Behind the scenes, a crucial mediator of the body’s inflammatory
