Yearly Archives: 2022
Can tremor, depression and progression of the Parkinson’s disease be suppressed simultaneously?
The short answer to this question is YES! Parkinson’s disease (PD) is the second most common age-related and progressive neurodegenerative disorder following Alzheimer’s disease (AD). It is associated with motor deficits such as loss of ability to
Campylobacter antimicrobial resistance in dogs and humans
Campylobacteriosis has been the most frequently reported zoonotic disease in humans in Europe since 2005, and the annual number of notified campylobacteriosis cases has increased in many European countries in recent years. The species most associated with
Importance of Cleanliness in Community Living
Everyone loves a clean and neat environment that is pollution free. However, few people take the necessary initiative to ensure cleanliness. Although there are government agencies and NGOs tasked with maintaining a clean environment, it is crucial
Turbulent flow simulation using a parallel discontinuous method
Turbulent flow is omnipresent in everyday life. When one flies in an aircraft or drives a car, the flow around the vehicle is mostly turbulent. Understanding turbulence has practical importance not only in improving passenger comfort and
Newly emerging drugs of abuse: A cat-and-mouse game
Recreational drug abuse and the resultant overdose have been a serious public health threat in the U.S. and the world. While traditional drugs of abuse remain popular, recreational use of newer synthetic drugs has continued to increase.
All You Need to Know About Protein Kinases
A fascinating field of biological study is that of genetics. Almost every ailment that a human can suffer from has some basis within their genes. As understanding grows within this ever-growing field of study, scientists are continuing
The allergies go marching on: the atopic march and the temporal relationship of allergic diseases
Atopic/allergic family of diseases affects >20% of the global population and encompasses allergic asthma, hay fever, food allergy, atopic dermatitis, and allergic rhinitis. Frequently, individuals with an allergic condition develop another allergic disease. The atopic march theory
The root is an ideal system to study magnetobiology in plants
Given that the origin and evolution of life had occurred in the presence of the geomagnetic field (GMF), it is possible that GMF information has been exploited by organisms as an important natural resource to tackle the
Short hydrogen bonds in proteins and their quantum mechanical nature
The assembly of linear polypeptide chains into functional three-dimensional protein architectures involves a unique force called hydrogen bonding. A typical hydrogen bond forms when the donor and acceptor groups approach each other with a nearly linear geometry
Modulation of intracellular dopamine signaling by aripiprazole may cause malocclusion as an extrapyramidal symptom
Aripiprazole, a dopamine partial agonist, is one of the most widely prescribed atypical antipsychotics and its use in children and adolescents has become common. However, due to its favorable side effect profile, its potential for inducing extrapyramidal
Role of dopamine in cortico-basal ganglia loop in psychosis
Dopamine plays a major role in the formation of acute psychosis, as indicated by the dopamine hypothesis of schizophrenia. The relationship between acute psychosis and the dopamine system provides insight into the effects of dopamine on brain
Defects in mismatch repair increase cancer risk and influence treatment selection
Microsatellites are formed by 1-6 nucleotide base pairs that are repeated in direct order 5-50 times. Repetitive DNA including microsatellites are mainly present in non-coding DNA regions that occupy more than 97% of the nuclear DNA. They
Is milk and meat from the offspring of a bull genome edited to have no horns safe to eat?
Horns on cattle are an animal welfare and human safety concern, but most high producing dairy breeds grow horns. Introducing the polled (hornless) trait into the dairy population by crossbreeding would also introduce non-productive traits by linkage
The Genetic Medicine Revolution — Eyes on the Future
Is the genetic revolution everybody talked about in 2001 after the human genome sequencing, here already? History and Background: It is astounding that as early as the 1960s, scientists speculated that DNA sequences could be introduced into
Postponed protonation under competitive conditions in rhodium catalyzed domino reactions
The readily available α,β-unsaturated compound (Michael acceptor) serves as one of the most important building blocks in synthetic chemistry, which is widely used in conjugate addition reaction. The characteristic of conjugate addition reaction is that it is
Deep Molecular Profiling to understand the biology of Alzheimer disease
Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged
Cosmology in a cell: Defect annihilation in liquid crystals
Topological defects are configurations of the order parameter which cannot be transformed continuously into a uniform state. They have been observed in various areas of physics, such as alloys, semiconductors, particle physics and cosmology. Due to the
Ultralong room-temperature phosphorescence of a solid-state supramolecule
Glows in the dark after removing energy input, named room-temperature phosphorescence (RTP), has got enormous attention because of its various application in biological imaging, light-emitting devices, information storage and encryption, and so on. However, achieving ultralong RTP
Essential fatty acids in the vegan/total vegetarian diet
People choose vegetarian/vegan diets and for many reasons, however, these diets require careful dietary planning. The essential polyunsaturated n-6 (omega-6) and n-3 (omega-3) fatty acids are required for synthesis of inflammatory compounds, cell membranes, skin, brain and
5 Equine Health Conditions Every Owner Should Know
Being an equestrian allows you to interact with one of the most majestic animals in the world – horses. It also comes with an immense responsibility to care for a horse and learn how to keep it
