Tag Archives: alzheimer’s disease
A new trehalose-conjugated peptide protects neurons from Aβ’s oligomers insult
Alzheimer’s disease (AD) is by far the most common cause of dementia affecting more than 35 million people worldwide. AD is characterized by memory loss, dramatic impairment of cognitive skills, and progressive body and mind decline ultimately
Management of apathy in the long-term care setting
Management of apathy is a very important issue in the long-term care because many residents with neurodegenerative disorders suffer from this syndrome. In Alzheimer’s disease, apathy is the most common behavioral syndrome and may occur already in
Trapping copper with peptides to diminish metal-related toxicity in Alzheimer’s disease
Metals are essential in many life processes and, as such, all organisms including our body have developed mechanisms for their uptake and tight regulation to achieve a normal functioning. Failure of these mechanisms is reflected in the
Early-onset Alzheimer disease: what are we missing?
Memory is the first brain function that starts to fade away when Alzheimer disease (AD) pathology affects the brain of a patient. Decline of additional cognitive functions, shortly follows. This progressive and irreversible disease, intrudes the life
Mutations in the SORL1 gene affect risk of early-onset Alzheimer’s disease
Alzheimer’s disease (AD) is the most common cause of dementia, leading to an enormous burden on societies worldwide. In brains of patients with AD, abnormal tangles of a protein called tau are found within nerve cells, in
Regional Alzheimer’s disease research
According to World Alzheimer Report 2015, over 46 million people live with dementia worldwide. The incidence of dementia is estimated over 9.9 million every year, and nearly half of new dementia cases (4.9 million) occurred in Asia.
One of the mechanisms of amyloid fibrils formation based on the sizes of folding nuclei of Aβ40 and Aβ42
Antibiotics and various advances in medical treatment have led to overall growth of life expectancy. However, along with positive aspects of prolonged life, humanity has faced a new challenge – age-related deceases. Parkinson’s disease along with Alzheimer’s
Differential courses of delay discounting in mild cognitive impairment and Alzheimer´s disease
People prefer to receive a reward rather sooner than later, which means that people put a smaller value on a reward they have to wait for (= delay discounting, DD). But when people get to choose between
Mapping brain shrinkage in dementia
Dementia is not a specific disease but rather an umbrella term for a collection of syndromes that affect thinking and behaviour. This is similar to cancer being the umbrella term for different cancer types, such as melanoma,
Sick arteries give their small cousins a beating: new insight into vascular pathology in Alzheimer’s disease
That the brain’s blood vessels, a.k.a. cerebrovasculature, play an important role in Alzheimer’s disease (AD) and related brain disorders is not entirely new. In fact, it was Alois Alzheimer and some of his contemporaries who observed gross
Vitamins and minerals in control of serious diseases?
We all know that vitamins and minerals are important, but why? The amino acid L-tryptophan is “essential” for mammals, and it must be obtained in the form of food. L-tryptophan can be utilized for protein synthesis, and
Self-reference effect on memory and well-being in patients at risk for Alzheimer’s disease
In cognitive psychology, the term self-reference effect (SRE) refers to the fact that individuals remember information better when the latter are related to themselves. This effect particularly boosts episodic memory, that is, the detailed memory of personal
Metabolic imaging is new a tool to investigate blood-brain barrier in Alzheimer disease
Alzheimer disease (AD) is the most common form of dementia worldwide. AD is characterized by progressive decline in cognitive functions. In the initial stages, deterioration of memory and loss of other intellectual abilities start to interfere with
Serotonergic drugs in the treatment of symptoms in Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative disease showing alterations in neurotransmitters, above all in brain regions responsibles for cognition and emotions. In this disease, an imbalance between neurotransmitters, acetylcholine, GABA, glutamate, noradrenaline and serotonin are included. In brain
Melatonin and serotonin in psychiatric and brain disorders
Melatonin is well known as a treatment for jet lag, being naturally released by the brain when we close our eyes to go to sleep. However, recent research shows that melatonin is released by many, if not
How antioxidants may have a pro-oxidant effect?
The main function of the consumption of antioxidants is to strengthen the activity of enzymatic antioxidant systems of our cells and this is intended to prevent or delay oxidative stress caused by the increase of reactive oxygen
Novel presenilin 1 mutation in familial late-onset Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive dementia, affecting over 20 million people worldwide, mainly adult subjects in advanced age characterized by loss of neurons and the presence of amyloid plaques in the brain. Several families have been
Music therapy eases depression, soothes agitation in nursing home residents with dementia
Did you know that around the world there are more than 35 million people living with dementia? People who are diagnosed with dementia, a progressively worsening disorder that affects memory, often experience a sad mood, agitation, and
Endocrine regulation of Alzheimer’s disease. The Achilles heel of dementia and other neurological conditions
Alzheimer’s disease (AD) is the most common disorder of the central nervous system and the most frequent cause of devastating dementia in the elderly. Typified by loss of memory and by cognitive decline, AD lowers the quality
Innovative tool, promise for treating Alzheimer’s disease and other neurodegenerative brain diseases
If at the dawn of the twentieth century, Alzheimer’s disease was seen as a rare disease, but today the incidence of this disease has taken epidemic proportions and is treated as one of the diseases of civilization.
