Diving into the mucus – PEG micelles for oral delivery
Swallowing a pill of paracetamol for headache is fast and easy. The drug can be administrated at a desired time and location without any pain or assistance. Such is not the case for biological drugs like insulin,
A powerful tool for the study of CD4 T cells in malaria
Although aimed at controlling invading pathogens, immune responses can sometimes be harmful to the host. Responses against the blood stage of malaria are an example of this: while B cells are activated and produce useful antibodies that
Why iron and copper may be harmful to the aging brain
Similar to other organs, brain function declines with age. Furthermore, age is the single greatest risk factor for Alzheimer’s disease as well as other neurodegenerative diseases. Both iron and copper increase in the brain with aging and
Profiling biologics in circulating human whole blood
Functional and safety assessments of biologics prior to first-in-human (FIH) is key to understand the mode-of-action and safety profile. We have made use of an ex-vivo whole blood assay for its potential in assessment of antibody-based drug
DIY materials will allow scientists and engineers to re-make the world
Human development has been based on making the best possible use of natural materials and resources – initially plants, wood, stone and metals, before the evolution of man-made materials such as plastics. All of these kinds of
World Congress on Lasers, Optics and Photonics. Barcelona, Spain. September 23-25, 2019
We take pleasure to announce World Congress on Lasers, Optics and Photonics (Optics-2019)” scheduled on September 23-25, 2019 at Barcelona, Spain. Optics-2019 aims to bring together leading academic scientists, researchers and research scholars to exchange and share
Subjectivity and molecular brain topology
It has become increasingly recognized that something essential is missing in the traditional interpretation of brain signals if this builds solely on the computer-metaphor (‘the brain as a computer’). In the frame of so-called ‘neural field models’
Novel targets for neuroprotection in neonatal brain injury
Developing brain is highly susceptible to injury. Together, prematurity and hypoxic ischemic encephalopathy (HIE) account for 50% of global mortality and significant neurodevelopmental impairment in survivors. HIE is a clinically defined syndrome of disturbed neurologic function due
3rd International Conference on Dentistry. Valencia, Spain. April 10-12, 2019
3rd International Conference on Dentistry (Dental-2019) is going to be held during April 10-12, 2019 at Valencia, Spain. International Conference on Dentistry includes Plenary lectures, Keynote lectures and short courses by eminent personalities from around the world
Acute ischemic stroke: Can clinical risk factors exclude more women than men from thrombolysis therapy
Acute ischemic stroke is the physiologic manifestation of lack of perfusion to the brain. This lack of blood flow may be secondary to thrombosis of a large vessel, an embolus from elsewhere that lodges into a smaller
4th World Dermatology Congress. Berlin, Germany. June 19-20, 2019
4th World Dermatology Congress, is independently organized by Meetings International held during June 19-20, 2019 in the beautiful city of Berlin, Germany. Our goal is to bring together bright minds to give talks that are idea-focused, and
Na/K pump mutations lead to hypertension by impairing Na+ and K+ transport
Aldosterone is a hormone that regulates blood pressure by increasing the amount of salt and water that your body retains as blood is filtered through the kidney. Aldosterone is produced by specific cells in the adrenal gland
One way traffic of wave propagations
Waves in waveguides can usually travel in both ways. When the conditions for coherent perfect channeling (CPC) are met, waves travel only in one way. The schematics of the three-waveguide system CPC are shown in Figure 1(a).
Emerging diversity of the CRISPR-Cas system in cholera phages
Interactions of bacteria and their phages, which are viruses hostile to bacterial survival lead to the evolution of numerous phage resistance mechanisms. CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated proteins) is such a defense system of bacteria. The
Organic synthesis provides 17,18-EpETE and isoleukotoxin diol in optically active forms
The epoxide ring opening of the trimethylsilyl substituted epoxy alcohol 1 (R1 = H) by CH3S(O)CH2Na (NaDMSO) produces anion 2 as the transient species, which undergoes an unusual reaction rather than the Peterson olefination (Fig. 1). When
Achieving synergistic biopolymer functions using systems chemistry
Biology succeeds by maintaining intricate networks of chemical and structural information far from equilibrium. The guiding premise of the highlighted manuscript1 asks whether synthetic and materials chemistry will be able to achieve a bottom-up construction of alternative
Amniotic membranes can ease the eye pain
The cornea is one of the most innervated tissues in the body. When the corneal nerves undergo damage from various causes (such as refractory dry eye, corneal burns and infections, refractive surgery, among others), abnormal nerve regeneration
How a cellular samurai may be linked to autism
Inside cells, a highly dynamic and ever-changing cytoskeleton network determines cell shape (permanent or temporary), powers movement (intracellularly or on a substrate), aids cell division and segregation of chromosomes in daughter cells, and supports cellular extensions like
Focal epilepsy in four generations of a 19th century family
Two main types of epileptic seizure disorder have been recognised for more than half a century. Generalised seizures begin in central areas of the brain and produce immediate loss of consciousness, sometimes with bilateral jerking or widespread
Glycans to reprogram the immune response
Glycans are structures composed of sugars or carbohydrates, which are highly abundant on all cells. These molecules serve many functions, including binding and communication between cells, movement of cells and maintenance of tissue structure. Glycans are crucial
