Unmet clinical needs in the treatment of systemic fungal infections. Reformulating repurposed drugs such as amphotericin B
A recent increase in the frequency of fungal infections has led to a higher number of fungal species that can cause these pathologies, as well as a decrease in the number of effective treatments against them due
Some questions remain unanswered for alpha-Crystallin
α-Crystallin together with β- and γ-crystallins make about 40% of the dry weight of fibrous cells in eye and 90% of all proteins. α-Crystallin is responsible for the eye lens transparency creating the necessary refractive index (1.4
Apoptotic cell’s dying wish is to be replaced
It has been estimated that out of ~37.2 trillion cells in an adult human, 50-70 billion cells die each day through the highly regulated programmed cell death, known as apoptosis. Thus, new cells must be generated to
Pain sensitivity and pain scoring in patients with severe obesity
There are indications that pain perception is altered in patients with obesity, which complicates postoperative pain treatment. An essential part for adequate pain treatment is the capacity of the patient to grade pain. Methods Forty-one patients with
12th Asian Biologics and Biosimilars Congress. Tokyo, Japan. August 20-21, 2017
12th Asian Biologics and Biosimilars Congress 2018 Organizing Committee invites you to attend the largest assemblage of biologics and biosimilars researchers from around the globe during August 20 – 21, 2017 at Tokyo, Japan. Asian Biosimilars Congress is
How to estimate small area health related characteristics of populations?
Health related characteristics of a population in a society are significant to health promotion programs and to the provision of better health services. The efforts of feasible health planning generally target local areas such as local health
Is a misophonia a new mental disorder?
We live in an era in which the major psychiatric classification systems, such as the successive editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM), have been steadily expanding in the number of phenomena that
An introduction to modelling lymphocyte migration in vitro
Lymphocyte recruitment to inflamed endothelial cells (EC) is fundamental to immune homeostasis – providing both cell-mediated defence against disease, while also contributing to the resolution of inflammation. However, the dynamic relationship between lymphocytes and EC can become
Inner myeloid gene network as a nexus of hematopoiesis and infection
The immunological system is equipped with efficient and tunable mechanisms to remove immediately pathogens from our body. Invasion of microbes in the blood is an emergency state, because they can trigger inflammatory responses, leading to sepsis. Therefore,
Go with the flow: Studying the movement of T-cells to sites of inflammation
Inflammation is the protective response of the immune system that aids the removal of invading infectious agents and repair tissue injury. It involves the movement of white blood cells (leukocytes) from the bloodstream, through the cells lining
Gulf Congress on Pharmacy and Pharmaceutical Sciences. Abu Dhabi, UAE. September 17-18, 2018
Gulf Congress on Pharmacy and Pharmaceutical Sciences scheduled on September 17-18, 2018 Abu Dhabi, UAE goes with the theme of the conference is Global Innovations & Recent Advancements in Pharmaceutical Science. Pharma Conference 2018 will be an
Acting in mechanisms of aging to delay/prevent Alzheimer’s disease
Alzheimer’s disease (AD), a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure. The disease is now on an ominous
How does your brain control interference from irrelevant information?
Given the continuous flux of visual information that competes for our attention in the everyday world, some form of attentional selection is needed to allow us to focus on what is relevant and ignore distracting information. This
New findings with therapeutic benefit in organ transplantation
Knowledge of the molecular mechanisms of cell death and understanding their fundamental role in a wide range of human diseases including myocardial infarction, stroke, sepsis, neurodegeneration, cancer, and organ graft ischemia-reperfusion injury, among others, is of major
What is a SERM and how does it work?
Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They
A new approach to improving the nutritional profile of fats in food products
Solids fats such as butter, shortening, or hydrogenated vegetable oils are a ubiquitous component of foods which contain a significant portion of liquid oil structured by a high-melting fraction, or “hardstock”. Fats contribute to many of the
Biodegradable microparticles used to prolong drug release to inhibit inflammation in osteoarthritis
Articular cartilage is located on the surfaces of the bones in the synovial joint. It protects the underlying bones from damage and shock, but also functions as a lubricant for frictionless movements of the human body. Damage
Prolactin regulates neurovascular coupling in male psychotic patients
Recent studies indicated that increased prolactin levels have negative effects on cognitive function in non-psychiatric populations and impair processing speed in patients with psychosis. According to the basic research, prolactin induces regional vasoconstriction via the inhibition of
‘DNA Fossils’, ancient mtDNA preserved in the nuclear genome: witnesses of human evolution milestones
Fragments of mitochondrial DNA (mtDNA) are known to get inserted into the DNA of the cell nucleus (i.e., our main genome) and to form NUMTs, i.e. dysfunctional sequences, nuclear pseudogenes of the mtDNA. Hundreds of NUMTs have
Human protein phosphatases: Proteomic insights
Protein phosphorylation-dephosphorylation, carried-out by kinase and phosphatases respectively, serves as major regulatory switch for controlling nearly all signaling processes. So far, the kinases remained a centerpiece in driving the functional response to signaling changes. However, more recently,
