Tag Archives: resistance
Perspectives for anti-tuberculosis therapy with additional drug activities to counteract drug resistance
Generally, antibiotic therapies use single antibiotics to combat sensitive bacteria. The standard of antituberculosis therapy includes four antibacterial agents that all have different modes of activities in the initial phase of a tuberculosis infection with mycobacterium tuberculosis.
A tale of pesticide use, resistance and the urge for One-Health
Edible olives and the production of olive oil dates to 5000 BC and, nowadays, it is estimated to occupy an area of 10.2 million hectares. More than 90% of the total area is in the Mediterranean Basin.
Gastrointestinal stromal tumor transition to KIT-independence is enabled by a Cyclin D1 dependent proliferation program
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. GISTs generally contain oncogenic gain-of-function KIT (~85%) or PDGFRA (~5-10%) mutations which are crucial for GIST proliferation and survival, as underscored by the
How does chromium cause lung cancer? Resistance to cellular stress
Lung cancer is the deadliest form of cancer in both men and women. One cause of lung cancer is occupational exposure to heavy metals. Extremely useful in several industries, heavy metals have become widespread environmental pollutants over
The importance of immature cancer cells in predicting patient outcome
The word “cure” for breast or any other type of cancer might be unfair to a patient since this will give the individual a false sense of comfort. The misuse of `cure’ is evident in breast cancer
RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies
Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with
20th-century version of an old pathogen. Drug resistant tuberculosis
Mycobacterium tuberculosis the causative agent of human tuberculosis (TB) is consider the most successful pathogen that could infect (2 billion), induce (10.4 million) and kill (1.7 million) a large number of people around the world. Besides this
Studying how hepatitis C virus resists certain drugs using computers and the internet
Hepatitis C virus (HCV) was not known to mankind until 1989. The discovery of this virus was possible due to the development of polymerase chain reaction (PCR) technology. Globally, around 180 million people are infected with this
Novel ROS1 mutations reveal a predictive mutational model for TKI sensitivity
In tumors with tumor-specific genetic alterations (i.e. 20-40% lung cancers), cancer cells are highly dependent on the function of a single oncogene, defined as ‘driver oncogene’ for their proliferation and survival. Many oncogene alterations have been identified
Simple mathematical formulas for tracking the number of antibiotic resistance cases globally
In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and
Inhibitors that reduce the acquisition of antibiotic resistance
The rapid emergence of antibiotic resistance is a worldwide crisis, endangering the efficacy of antibiotic treatment. A recent article in Scientific America (December 16, 2014) highlights the importance of developing strategies for reducing antibiotic resistance and prolonging
Are disinfection processes an effective barrier in controlling the spread of antibiotic resistance in the environment?
According to the report on global surveillance of antimicrobial resistance published in 2014 by the World Health Organization (WHO), the world is heading towards a post-antibiotic era, in which common infections and minor injuries may once again
Fecal microbial transplantation: a novel approach to eradicate antibiotic-resistant gut bacteria
The discovery of antibiotics in the early 20th century had an enormous impact on modern medicine, dramatically reducing mortality associated with infections. However, the emergence of drug – resistant pathogens has occurred due to greater availability and
Can solar driven processes effectively control antibiotic resistance and cytotoxicity during drinking water treatment?
Antibiotics, antibiotic resistant bacteria and antibiotic resistant genes have been detected in various aquatic environments because of the disposal of both treated and untreated wastewater. Their occurrence in water is a threat for human and animal health
Rapid and extremely reliable detection extended-spectrum ß-lactamases-producing Enterobacteriaceae
Resistance to antibiotics is becoming a worldwide issue mostly related to resistance observed in gram negative bacterial species such as in Enterobacteriaceae (Escherichia coli , Klebsiella pneumoniae) that are the most important source of hospital – and
Anthelmintic resistance or what left after the incorrect treatment?
Small ruminant gastrointestinal parasites represent very important and common problem in the world (Fig. 1). Infections with gastrointestinal nematodes can have a detrimental effect on animal health such as weight losses, diarrhea, anemia, digestion problems and even
Targeted exercise intervention for bradykinesia in Parkinson’s disease
Exercise has been used as an intervention for many diseases; however, to maximize the benefits of any exercise intervention there we must understand that exercise is not a blunt, unidimensional tool; but rather, a malleable prescriptive instrument
The antibacterials that have yet to be found
Science has contributed greatly to prolong the lifespan and health conditions of humans. However, close to the coming of age of the XXI Century, humankind is confronting the global war against infectious diseases. Leaving aside other microorganisms-associated
Plasmid-mediated carbapenem and colistin resistance in E. coli – toward a dead end
The increasing trend in antibiotic resistance continues to threaten global health. Presently, multidrug resistance (MDR) in gram-negative rods is frequently observed not only with the occurrence of extended-spectrum ß – lactamase but also with producers of enzymes
Fatty liver disease: a condition caused by modern day lifestyle
Non-alcoholic fatty liver disease (NAFLD) refers to the build-up of fat (steatosis) in the liver that occurs in the setting of obesity and/or diabetes. Specifically, other causes such as alcohol excess or drugs or genetic conditions need
