Mechanistic analysis of antimicrobial peptide membrane interactions by molecular dynamics simulation
The world emergence of the bacterial superbugs has limited the effectiveness of the available antibiotics in the clinic. Because of the multifaceted antimicrobial mechanism of actions, cationic antimicrobial peptides (AMPs) may be considered as promising molecules to
Understanding how liposome composition and manufacturing affect docetaxel encapsulation and cell killing
Docetaxel (DTX) belongs to a class of anticancer drugs clinically used to treat a plethora of cancers, including breast and prostate cancer. DTX works by interfering with the cell cycle and blocking cell proliferation. Although being a
A culturally adapted lifestyle intervention among Middle-Eastern immigrants in Sweden
In Sweden, there is an increasing immigrant population of which a large proportion originate from the Middle East. Middle East is one of the areas with highest diabetes prevalence in the world. Middle-Eastern immigrants in Sweden have
Bioinformatics at the cutting EDGE: Empowering the Development of Genomics Expertise
An in-depth understanding of how microorganisms function is required to address many challenging issues facing society today such as understanding how to eradicate infectious diseases and mitigate climate change. Answers are held in their genetic code. Advancements
Is ecotype difference in switchgrass a reflection of photosynthetic efficiency?
Switchgrass, a warm season perennial grass native to the North American Prairie, is a potential cellulosic feedstock for biofuel production in the United States. Using switchgrass for bioenergy production is environmentally friendly and economically feasible. It is
Children and their parent’s terminal illness: The role of doctors and nurses
The diagnosis of a terminal illness is a stressful event. However, when patients have dependent children (children under the age of 18 years) there are additional anxieties, uncertainties and stressors. A concern for parents is about how
SLiMming the fuzz in gene-regulating interactomes
Organisms depend on strict regulation of their genes for proper cellular function. This regulation is mediated by large protein interaction networks – the so-called interactomes. By analogy to the World Wide Web, interactomes display a scale-free architecture
Gamma irradiation on canola seeds and crop-insects interactions
Plant breeding by gamma irradiation is one of the most important anthropogenic forces that influences ecosystem function and structure. It has been reported that gamma irradiation can affect the morphology, anatomy, biochemistry and physiology of plants that
Urea is truly toxic: the empire strikes back
Urea is a metabolic waste product that accumulates in the body in the setting of chronic kidney disease. It is routinely measured on blood tests as a marker of kidney function (higher urea levels indicate lower kidney
Divorce can be good for health in traditional societies such as China
China has achieved impressive economic growth during the last three decades due to rapid industrialization that has been facilitated by “Special Economic Zones”. In addition, internal migration of over 150 million workers from rural to urban areas
A novel regulator for the generation of muscle stem cells
The skeletal muscle is the largest organ in human body and plays a key role in locomotion and systemic energy homeostasis. Muscle dystrophy and atrophy often leads to frailty and fatality, underscoring the importance for maintaining proper
Molecular players behind sunflower architecture: differential transcription of two genes
During plant embryogenesis the primary axis of development is established by two groups of pluripotent cells: the shoot apical meristem ( SAM ), responsible for aboveground organs generation, and the root apical meristem (RAM), responsible for underground
Muscle memory creation: is tactile feedback alone enough?
Surgeons optimize their performance during a procedure based on multiple information received via eyesight, hearing or tactile feedback. The question remains of how much information can a surgeon take through tactile feedback? This research was motivated by
What about the real costs of next generation sequencing (NGS) in human genetic diagnostics?
Human genetics diagnostics (HGD), which always has to go together with human genetic counselling, is a rapidly developing field. HGD may become necessary in case of familial cancer syndromes, infertility, prenatal abnormal sonography or a child born
Phosphate dissolving fungi: a sustainable alternate for soil P nutrition
Phosphorus (P) is an indispensable element for plants due to its role in photosynthesis, respiration, energy storage and transfer and cell division. Its low availability in soil may limit the agricultural production in the next millennium. The
Live-cell imaging revealed the dynamics and the roles of cytoskeleton in polarizing plant zygote
Asymmetric cell division is one of the fundamental steps to form the plant body axis. In most flowering plants, the apical-basal axis is established by the asymmetric division of the zygote. In a model plant Arabidopsis thaliana,
What’s new in the plankton?
There is considerable interest in changes in species distributions related to climate change and the phenomenon of invasive species. Obviously, identification of a species as new to a given area requires near complete knowledge of the species
Soil remediation: a potential way of turning lignin waste to wealth
With the rapid economic development and industrialization, an increasing amount of agricultural and urban soils has been polluted in recent years. Among various kinds of pollutants, metal pollutions have paid much more attention. Unlike organic pollutants, metals
Use flat shoes and increase neurogenesis!
When starting to walk the plantarflexor triceps surae muscle is inactivated, the dorsiflexor tibialis anterior activated, and we fall forward because of gravity. The first step is taken, and just as the foot leaves the ground, we
