Tag Archives: apoptosis
The suitability of scopolamine as an Alzheimer’s model
Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of
When cell death is better than cell survival: Monocyte response to lysates from different strains of Campylobacter jejuni
Campylobacter jejuni, a Gram-negative pathogen, is one of the leading bacterial causes of gastroenteritis world-wide. The invasion and multiplication of C. jejuni is a multistep process that includes interaction with the intestinal epithelial cells (IECs). The only
How to detect dying neurons in the central nervous system?
The central nervous system (CNS) changes dynamically throughout an animal life. In the fruit fly, Drosophila melanogaster, asymmetric mitosis of the neuroblasts during embryonic development produces about 10,000 differentiated neurons that form a juvenile (larva) CNS. These
Cellular assay: bottleneck of the drug discovery process
Finding a needle in the haystack is not that difficult after all: Just use a strong magnet, and you have a good chance to get it. Picking up, among millions of different compounds, the right ones that
Apoptotic cell’s dying wish is to be replaced
It has been estimated that out of ~37.2 trillion cells in an adult human, 50-70 billion cells die each day through the highly regulated programmed cell death, known as apoptosis. Thus, new cells must be generated to
Targeted nanoparticles for molecular imaging
Oncologic, cardiovascular, and neurological diseases are the most common causes of death in the developed world. It is well established, especially for cancer that early diagnosis results in more favorable outcomes. Although various diagnostic tests are available
Vodka and wine consumption: good for your liver?
Approximately 50 million Americans are affected by metabolic syndrome. Metabolic syndrome is defined as hypercholesterolemia, hypertriglyceridemia, high blood pressure and glucose intolerance leading to type 2 diabetes mellitus. Patients with metabolic syndrome have an increased risk of
Lymphocytes T and Treg as prognostic factors of newly diagnosed DLBCL patients
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and most common form of non-Hodgkin lymphoma. The mechanism of DLBCL pathogenesis is not fully understood. Malignant B-cells responsible for lymphoma formation are believed to arise from different stages
Epithelial wound healing: a matter of life and death
Wound healing is a crucial property for the maintenance of the structural and functional integrity of an individual. In the whole organism it usually requires the participation of many cellular types. The fundamental aspects of wound healing,
MSX1 sensitises cells to ovarian cancer treatment
Ovarian cancer is an insidious disease which in the majority of cases is diagnosed only at a very late stage. The majority of ovarian tumours are of a particular aggressive type, called high grade serous ovarian cancer.
Aging is adaptive
Aging is a lifecycle stage common to all life forms and is observed in both unicellular and multicellular organisms. The primary manifestation of aging in unicellular organisms is replicative senescence. As the cell ages, cell cycles become
Fluorescent carbon dots integrated hydrogels for lung cancer therapy
Cancer is considered as one of the leading cause of death worldwide. Due to the ever changing lifestyle of the modern society, the incidence of cancer is on the rise. Lung cancer is the most frequently diagnosed
Alternative splicing: the new frontier in diabetes research
The human genome is predicted to contain 22.000 coding genes, but more than 200.000 proteins are expressed in human cells. This discrepancy is explained at least in part by the presence of alternative splicing (AS), a key
Nitric oxide trigger apoptosis in the brains in Border Disease
Border disease is a pestivirus infection accompanied by central nervous system (CNS) and skeletal abnormalities in sheep and goats. Affected fetuses and newborn animals exhibit brain disorders. This study investigated the relationship between the severity of the
More reasons to appreciate the Golden Spice “saffron”
Cancer remains a leading cause of morbidity and death worldwide. What is even worse is that the number of new cancer cases is projected to massive increase which would probably make it the first cause of death
ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration
Neurons, the major component of our brain, have long processes (called “axons” and “dendrites”) to communicate with other neurons and cells. In many brain diseases that old people get suffered from, such as Alzheimer’s disease, Parkinson’s disease,
Small-molecule RETRA is effective against a fatal childhood cancer
The bone tumor Ewing’s sarcoma is one of the most aggressive cancers in childhood and adolescence. Before the era of chemotherapy, more than 90% of Ewing’s sarcoma patients succumbed to their disease. With the introduction of intensive
Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s
An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric
A combination therapy to induce apoptosis in difficult-to-treat cancer cells
The presence of activated PI3K-AKT is a major obstacle to successful chemotherapies. Since PI3K-AKT is activated in many healthy tissues, chemical inhibitors of PI3K-AKT inevitably have many unwanted side effects. By using a cholesterol-targeting drug called beta-cyclodextrin
New effective treatments for Alzheimer and Parkinson’s disease
Alzheimer and Parkinson’s disease are the most common neurodegenerative disorders. As people are getting older than in previous generations, the number of people who are affected has increased. Unfortunately, there is no cure for these diseases. The
