Tag Archives: fibrosis

Macrophage-myofibroblast transition: a novel target for stopping kidney disease

AoS.Macrophage-myofibroblast transition

Kidney is one of the major organs in our body for detoxification. Its failure is an important cause of patient mortality that serves as a primary disease and a lethal complication in a range of diseases such

The use of dry powder mannitol in respiratory disease

The use of dry powder mannitolin respiratory disease

Asthma is an inflammatory disease of the airways causing them to be hyperresponsive to a wide range of stimuli. It is a common disease both in children and adults and most asthmatics suffer from allergies and from

Clubbing in patients with fibrotic interstitial lung diseases

Many years ago Hippocrates already described clubbing. Clubbing is a deformation of the nail base resulting in a swollen and spongy convex. It is frequently seen in patients with interstitial lung diseases (ILDs). ILDs contain a variety

Excessive vascular fibrosis predicts early failure of hemodialysis fistulas

Patients with end-stage renal disease require a functional vascular access to receive hemodialysis and prolong their lives. The arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis. The AVF is surgically created by connecting a superficial

Ultrapure cells for liver research

Worldwide, hepatic fibrosis, cirrhosis and hepatocellular carcinoma cause considerable human suffering and high economic burdens. Causally responsible for the accumulation of excess scar tissue within the diseased liver are hepatic stellate cells (HSCs) representing 5-8% of the

Urea is truly toxic: the empire strikes back

Urea is a metabolic waste product that accumulates in the body in the setting of chronic kidney disease. It is routinely measured on blood tests as a marker of kidney function (higher urea levels indicate lower kidney

The capillary web gets lost in diseased kidneys

Main functions of the kidney are regulating ions, pH, fluid balance and blood pressure and disposing of metabolic waste products. These functions are dependent on properly working renal blood vessels, including the smallest ones, the so called

Not remodeled left atria and mitral regurgitation: what learn from microstructure

Chronic mitral regurgitation (MR) is the most common type of heart valve disorder, frequently characterized by left atrial (LA) enlargement as a compensatory mechanism. This change in LA dimension may increase the risk of atrial fibrillation (AF)

Non-invasive whole-body imaging of fibrosis: is it feasible?

Fibrosis is a chronic, life-shortening disease that can occur either as a consequence of genetic defects or in response to inflammation or damage. Such body systems as respiratory, gastrointestinal, musculoskeletal, genitourinary, and reproductive can be affected. Fibrosis

Dual pathways of aortic degenerative change; Calcification and Fibrosis

Aortic stenosis (AS) is the most common type of valvular heart disease and its prevalence increases exponentially with age. Degenerative changes continue to be the most common pathologic causes. In terms of pathologic AS phenotypes, there are

PDGF-D – a potential novel treatment for kidney diseases with scaring

Estimates suggest that a huge number of people, more than 10% of the world-population, are suffering from chronic kidney disease. Chronic kidney disease eventually leads to complete loss of kidney function, which is fatal if not treated

CCN proteins : A new vista for molecular medicine

The CCN family of proteins is composed of six members playing critical biological roles, both in normal and pathological conditions. The first three CCN proteins discovered were designated Cyr61, Ctgf, and Nov because of the context in

Fish gills help understand human lung disease

Persistent inflammation of the lung leads to fibrosis, a serious and poorly understood disease that causes scarring of the lungs. A poor prognosis of only approximately 3 years survival after diagnosis demonstrates the lack of understanding of

Cerium oxide nanoparticles may be of therapeutic value in chronic liver disease

What is this? We use Cerium oxide NPs (CeO2NPs) to treat cirrhosis in model rats and we observe how it has dramatic beneficial effects in reducing inflammation and allowing tissue reparation What makes nanoceria very appealing is

Osteopontin is a novel player and potential biomarker in hepatosplenic schistosomiasis mansoni

Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma. Over 440 million people from 76 countries and territories are infected (Fig. 1). This water-based disease is considered the second most important parasitic

AZGP1, a new candidate for the treatment of chronic kidney disease

In elderly populations, chronic kidney disease is a common clinical problem associated with a high degree of morbidity and mortality. When the kidney is injured by, for example, low blood flow, the human body has a remarkable

Gene therapy: a promising candidate for cystic fibrosis treatment

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular

Updates on the pathophysiology of systemic sclerosis

Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with autoimmune component, inflammation, and progressive fibrosis of conjunctive tissues of the skin and internal organs. Lung involvements are a major cause of concern as pulmonary fibrosis and

Botox injections: a “bittersweet” medicine

Despite being one of the most deadly neurotoxins known to man, Botox has become a popular cosmetic treatment for reducing facial wrinkles. Originally, Botox injections were used for reducing uncontrolled movements caused by neuromuscular disorders that impaired

Resveratrol is a potential remedy for the treatment of pancreatic fibrosis

The pancreas serves as both endocrine and exocrine glands in a human body in order to help food digestion and blood glucose regulation. In fact, more than 90% of the pancreatic mass comprises the exocrine cells which