How to stain E-selectin ligands in tumor tissue
Cancer affects millions of people around the world. Nowadays they have more chances to survive, but still, the most frightful scenario are metastases. Few patients with metastases survive, and there is an unmet clinical need for new
Milk and beef: Do production enhancing hormones pose a health risk?
After World War II, a sharp increase in demand for beef and dairy products, coupled with a burgeoning veterinary pharmaceutical industry, led to a number of changes in animal husbandry, including a reliance upon exogenous hormones to
Heat, diet and lifestyles control longevity in animals and man
The inactivation of the heat shock gene called Sirtuin 1 (Sirt 1) is associated with many chronic diseases such as diabetes, non alcoholic fatty liver disease (NAFLD), cardiovascular disease and neurodegenerative diseases. Factors such as body temperature
Control of doping in racing pigeons
Pigeon racing is considered a popular sport in several countries such as Belgium, England, Netherlands, Portugal, Japan, Taiwan and South Africa. In all these countries, pigeon racing is a federated sport and racings take place on a
Chemical toxicity study of some Algerian medicinal plants
About 65 to 80% of the world’s population use traditional medicine for their primary health WHO according to the WHO report. However, the use of herbal medicines has come under scrutiny due to their perceived long-term toxicity
Molecular targeted therapy in alveolar soft part sarcoma
Alveolar soft part sarcoma is a malignant and rare tumor that includes about 1% of all STS (soft tissue sarcoma), and usually occurs in adolescents and young adults. This type of cancer has tendency toward distant metastasis
Can tree rings be used as pollution bioindicator archives to reconstruct past environments?
Trace heavy metal (HM) pollution over time and space is becoming a growing global problem, as many studies have confirmed that human activities have dramatically increased natural concentrations of metal pollutants in the last century. HM are
Development of the Japanese version of the Kinesthetic and Visual Imagery Questionnaire (KVIQ)
Motor imagery is commonly defined as the mental simulation of one’s own performance without any associated overt movement (Jeannerod M, et al. Behav Brain Sci. 1994). Previous studies have suggested that motor imagery increases motor skill acquisition
Rethinking drugs’ development in acute heart failure?
Acute heart failure (AHF) affects 1-2% of adults in developed countries. It strikes mainly people above the age 60, peeking in those older than 85 (prevalence ~ 17.4%). AHF is a life threatening medical event, with gradual
Strategies to enhance antioxidant potential and biosynthesis of essential oils in Ajuga bracteosa
Essential oils are the plant-derived natural products and are called “essential” due to the essence of the distinctive fragrance they contain, specific to the fragrance of the respective plant from which they are derived. A large portion
Evolution of the art and science of kidney transplantation in HIV positive patients
Once considered prohibitive, kidney transplantation in HIV (+) recipients is achieving outcomes similar to comparable recipients without HIV. These successes are possible because of incremental improvements in care that resulted from lessons learned from the last two
Early – life seizures: alarm bell for often severe clinical outcome
Early life seizures (ELS) are a not uncommon clinical manifestations in infancy affecting from 1.8 to 3.5/1000 live birth. In infancy with rare exception of seizures typically benign which include the Benign Familiar Neonatal Epilepsy (BFNE), Febrile
Engineering long-wavelength light-driven ion channels to hear the light
Optogenetics enables the remote control of neuronal activity by light. This is accomplished by channelrhodopsins, light-sensitive molecular switches, which are integrated into the neurons by adeno-associated viruses (AAVs)as gene ferries. AAVs are convenient and safe for gene
A new immune signature in people with Polycythemia vera: a modulator of disease progress?
Polycythemia Vera (PV) is a disease in which your body makes too many red blood cells (RBC), whose main function is to transport oxygen from the lungs to all parts of your body. The many circulating RBC
Rethinking how we pay for conserving global biodiversity
In our article in Science, “How to pay for saving biodiversity”, my co-authors and I argue that it is time to rethink the global approach to saving the world’s remaining biodiversity and habitats. Twenty-five years after establishing
The pitfalls of PGT-A and scoring of mosaic embryos
Preimplantation genetic testing for aneuploidies (PGT-A) or formerly known as preimplantation genetic screening (PGS), is genetic testing for numerical (aneuploidy) and structural chromosomal aberrations in IVF-embryos. Most aneuploidies including several structural chromosomal aberrations are not compatible with
Hearing loss in autoimmune disorders
Autoimmune sensorineural hearing loss (SNHL) is a rare clinical entity accounting for less than 1% of all cases of hearing loss; however, this could be an underestimation based on the absence of specific diagnostic tests and the
Mitochondrial Complex I activity signals antioxidant response through ERK5
The vast majority of eukaryotic cells perform oxidative phosphorylation (OXPHOS), which uses the energy released by the mitochondrial oxidation of certain metabolites, i.e. glucose, to produce adenosine triphosphate (ATP). OXPHOS is highly efficient in energy production but
Adult-onset biotinidase deficiency
Biotinidase is the enzyme that recycles the water-soluble vitamin, biotin, which is the coenzyme for four carboxylases that are involved in gluconeogenesis, fatty acid synthesis, and in the catabolism of several branch-chain amino acids. Biotinidase deficiency (BD)
Immunogenicity and safety of the new inactivated quadrivalent influenza vaccine Vaxigrip Tetra
Influenza represents an acute viral respiratory disease caused by RNA-enveloped viruses. They belong to the Orthomyxoviridae family which comprises five genera, but only two (influenza A and B viruses) are of medical relevance in humans. Even though
