College drinking culture in Spain, Argentina, and USA: An examination of impulsivity, college alcohol beliefs, and alcohol outcomes
Across many countries and cultures, college students drink heavily. Students who drink heavily are at risk for a wide range of problems ranging from hangover to unsafe and unplanned sex to poor academic performance to developing an
Treatment of elderly patients with pancreatic cancer
Our publication is about elderly patients’ treatment evaluation for pancreatic cancer in the United States. This is a Surveillance, Epidemiology, and End Results (SEER)-Medicare analysis of patients above age of 65 who have Medicare and were treated
Nucleophosmin holds it all together, the smart glue of the nucleolus
The nucleolus is an organelle that serves as a factory for ribosome production and a stress sensor in the nucleus of eukaryotic cells. Unlike the nucleus, the nucleolus is not surrounded by a membrane. Instead, the nucleolus
Fibroblasts in rheumatoid arthritis: From friend to foe
Our joints are composed of tissue-resident cells, called fibroblasts, which are responsible for maintaining the structure of the joint and repairing damaged tissue. Additionally, we and others have shown that fibroblasts can also influence the types and
TussisWatch: a smartphone system to identify cough episodes as early symptoms of chronic diseases
Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF) are progressive diseases and often the terminal stage of heart and lung disease, leading to death and disability. Both of these diseases may manifest with similar conflicting
The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors
Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in
A culture medium for screening pandrug- resistance to aminoglycosides in Gram-negative bacteria
Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising the efficacy of several class of antibiotics such as beta-lactams and aminoglycosides. Therefore, it is essential
Pathophysiological advantages derived from simultaneous measurement of diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO)
It has been over 100 years since Marie Krogh developed the method to measure the transfer of carbon monoxide (CO) through the alveolar wall. Since then, the single-breath CO diffusing capacity (DLCO) has become the most clinically
Counting choline: why this nutrient is important and how we can measure it
Choline is an important nutrient for the growth and sustenance of living things, from humans to bacteria. Cells covert choline into phosphocholine via the activity of the enzyme choline kinase, and a change of other enzyme mediated
Sea-level rise: a big push to increase plant root zone’s subsurface water salinity level
In coastal east-central Florida (ECF) in the U.S. (Fig. 1), plant root zone’s (PRZ) subsurface water salinity level is crucial to the survival of various vegetation species because it is one of the dominant factors controlling seed
How does chromium cause lung cancer? Resistance to cellular stress
Lung cancer is the deadliest form of cancer in both men and women. One cause of lung cancer is occupational exposure to heavy metals. Extremely useful in several industries, heavy metals have become widespread environmental pollutants over
Second-generation composites from recycled wind turbine blades
The demand for wind and other forms of clean energy is increasing in the US and throughout the world. Wind energy is also expected to provide 14.9% of the global electricity demand by 2020. Under this scenario,
Insights into the molecular basis of posterior polymorphous corneal dystrophy
Posterior polymorphous corneal dystrophy (PPCD) is a rare autosomal-dominant disease affecting the innermost part of the cornea, termed the endothelium. This monolayer of cells maintains corneal transparency by regulating its hydration. Human corneal endothelial cells do not normally
Large animal models for osteoporosis research: The small ruminants (sheep and goat)
In the healthy skeleton, constant bone remodeling occurs in which mature bone tissue is removed, in a process called resorption, and new tissue is formed in order to maintain bone strength and mineral homeostasis in continuum with
Metabolic and non-metabolic roles of pyruvate kinase M2 isoform in retinal rod photoreceptor cells
Glucose is the main source of fuel for every living cell. Normal cells take up glucose and burn it in the mitochondria (oxidative phosphorylation) for energy production (ATP synthesis). Rapidly dividing cells, such as cancer cells, and
Advances in drug discovery and development in geriatric psychiatry
Drug discovery for disorders of the central nervous system is a long and challenging process, with a high attrition rate from the preclinical stages through to marketing a compound. In geriatric psychiatry, the heterogeneous nature of these
Chemotherapy and radiotherapy in abdominal sarcoma
Soft tissue sarcomas (STS) are a rare group of cancers that arise in connective tissues such as muscles, fat and blood vessels. STS can occur almost anywhere in the body but are most commonly found in the
Clostridioides difficile infections: what is new in laboratory diagnosis and clinical treatment
Clostridioides difficile infections (CDI) have become a major economic issue from developing countries as well as from the Western World. Early and accurate diagnosis of CDI allows earlier treatment, which can significantly reduce the morbidity, mortality, medical
The silent effects of heart surgery: voice and swallowing
Heart disease is a leading cause of death worldwide. Heart surgeries saves thousands of lives a year but can be lengthy and complex. During surgery, many patients require prolonged periods of intubation and coronary bypass (mechanical support
The destruction of endocrine disruptors in wastewater
In Canada, endocrine disruptors are a very topical issue in wastewater effluent quality. We define endocrine disruptors as chemicals that can interfere with the endocrine or hormone systems in wildlife and humans. Results can vary from different
