The journey of an Indian pediatric cardiologist
The journey of an Indian pediatric cardiologist, who gave substantial attention to advance new knowledge and teach/train physicians around the world while providing care to patients with heart disease over a 45-year period, is examined. This review
Melatonin play wonders in Zinc oxide nanoparticle induced toxicity
Over the past several decades, the field of nanotechnology has perceived an uplifting graph of achievements and developments. Among the principal nanoparticles contributing for the same, ZnO nanoparticles should be considered as the foremost. By having unique
Novel biophysical assay reveals that bacterial cell wall maintaining proteins change interaction conformation based on activity
Bacterial infections are increasingly difficult to treat with antibiotics due to antibiotic resistance. Knowledge on how of bacteria multiply needs to be profoundly expanded as a requirement for the development of new methods for the discovery of
Dental and temporomandibular joint pathology of the North American brown bear
Maxillae and mandibles of 393 North American brown bears (Ursus arctos) housed in the Museum of the North, University of Alaska, Fairbanks were examined macroscopically according to predefined criteria, with 204 specimens meeting inclusion criteria. The museum
A novel biomarker for oral cancer
Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked
Unveiling toxicity concerns of PEGylated reduced graphene oxide
Graphene, a 2D carbon material tagged as the “strongest material” that forms a honeycombed lattice structure has found profound application in biomedical field owing to its exciting physico-chemical properties. It has raised global acceptance and enthusiasm in
Osteoarthritis of the wrist: Improved understanding of wrist movements leads to novel advancement in wrist replacement surgery
Like every other joint in the body covered by cartilage, the wrist can develop osteoarthritis. Many treatments have been attempted including cutting sensory nerves to relieve pain, stiffen the wrist, partially removing some of the joint and,
Colorectal cancer and enteric neurons: Should tumors be nervous?
Colorectal cancer (CRC) is one of the most frequent types of cancer in the world and is associated with a high mortality rate with over 700.000 deaths per year. Throughout the past decades, the development of CRC
Progressive multifocal leukoencephalopathy in idiopathic CD4 lymphocytopenia
Progressive multifocal leukoencephalopathy (PML) is a life-threatening demyelinating disease of the central nervous system caused by reactivation of the virus JC (JCV). This condition is triggered by immunosuppression, most frequently associated with AIDS, lymphoprolioferative diseases or immunosuppressive
Iodinated trihalomethanes in waters: a new class of toxic disinfection by-products
Disinfection of water supplies started in the early 1900s to reduce risks to public health from pathogenic microorganisms. Chlorination is the most common disinfection practice, achieving effective primary disinfection and sufficient disinfection residual in drinking water distribution.
We are all different. Even when we look at saliva!
Saliva has increasingly been used as a diagnostic fluid since it is easier to collect and process than blood and it has similar diagnostic capabilities. Total protein profiles can be obtained from saliva by capillary electrophoresis and
Pharmacological approaches targeting immune cell and oxidative biology in allergic asthma
Airway inflammation is one of the central features of asthma and chronic obstructive pulmonary disease (COPD). The mechanisms associated with the development and progression of airway inflammation have been widely studied in multiple populations and animal models.
Post trauma: to filter or not to filter
Pulmonary embolism (PE) remains a significant cause of death in trauma patients. However, this patient population is also at risk of ongoing bleeding, making anticoagulation (Heparin, Coumadin, etc.) impractical. This puts trauma surgeons and vascular surgeons alike
Zebrafish is an attractive model to anticipate drug-induced renal injury in humans
Most of the innovative drugs with important therapeutic benefits are not approved or are removed from the clinical practice due to drug-induced toxicity. The kidneys are one of the most important target organs of drug toxicity because
Bioinformatics solutions for big data analysis in life sciences presented by the German network for bioinformatics infrastructure
Over the last decade, the amount of data generated by life science research has grown at a rapid rate and an increased complexity rendering the tasks of data analysis, management, and storage a unique challenge. To meet
Acridone-pyrimidine hybrid molecules: potential anticancer agents
Cancer is one of the world’s most pressing challenge to research community and leading cause of death. As per the 13th report of American Science of Clinical Oncology, 14 million people are diagnosed with cancer every year.
Role of lymphadenectomy in non-small cell lung cancer surgical management
The prognosis and survival of non-small cell lung cancer (NSCLC) patients is dependent on the stage of disease, which is based on tumor size and nodal and distant metastasis at presentation. In turn, cancer stage assessment is
Role of the gut in systemic inflammation
The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly
An in-silico meta-analysis of cell-type-specific non-CpG methylation
Nowadays, the amount of raw data required for a genome-wide analysis is quite large and it is often difficult for even its original author(s) to spend enough time for its thorough analysis. Further, it would be practically
